BRD-K66296774_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K66296774_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
BST2 bone marrow stromal cell antigen 2
C8ORF4 chromosome 8 open reading frame 4
CD99 CD99 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DMD dystrophin
EDN3 endothelin 3
ERBB2 erb-b2 receptor tyrosine kinase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FOLR1 folate receptor 1 (adult)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP2 guanylate binding protein 2, interferon-inducible
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP6 insulin-like growth factor binding protein 6
JUN jun proto-oncogene
LY6D lymphocyte antigen 6 complex, locus D
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP12 matrix metallopeptidase 12
NEFL neurofilament, light polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5DC2 5'-nucleotidase domain containing 2
PEG3 paternally expressed 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMP2 peripheral myelin protein 2
PRKCD protein kinase C, delta
RHOBTB3 Rho-related BTB domain containing 3
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
STAT1 signal transducer and activator of transcription 1, 91kDa
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
ALCAM activated leukocyte cell adhesion molecule
ARHGAP29 Rho GTPase activating protein 29
ATG3 autophagy related 3
CAV1 caveolin 1, caveolae protein, 22kDa
CBX3 chromobox homolog 3
CCND1 cyclin D1
CD200 CD200 molecule
CD38 CD38 molecule
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CTGF connective tissue growth factor
DCLK1 doublecortin-like kinase 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DUSP6 dual specificity phosphatase 6
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FADS1 fatty acid desaturase 1
FGG fibrinogen gamma chain
G0S2 G0/G1 switch 2
GPX7 glutathione peroxidase 7
HDAC9 histone deacetylase 9
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KLK11 kallikrein-related peptidase 11
KRT23 keratin 23, type I
MOK MOK protein kinase
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPTX2 neuronal pentraxin II
NTS neurotensin
NUAK1 NUAK family, SNF1-like kinase, 1
PEG10 paternally expressed 10
PRSS23 protease, serine, 23
QPCT glutaminyl-peptide cyclotransferase
RGS2 regulator of G-protein signaling 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SRSF6 serine/arginine-rich splicing factor 6
TBPL1 TBP-like 1
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMPRSS3 transmembrane protease, serine 3
VCAM1 vascular cell adhesion molecule 1