BRD-K66254772_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

48 genes differentially expressed following the BRD-K66254772_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
CBR3 carbonyl reductase 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK6 mitogen-activated protein kinase 6
MFAP3L microfibrillar-associated protein 3-like
NQO1 NAD(P)H dehydrogenase, quinone 1
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TUBB2A tubulin, beta 2A class IIa
UGDH UDP-glucose 6-dehydrogenase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
C7 complement component 7
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHRDL1 chordin-like 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
HOXA10 homeobox A10
MYH11 myosin, heavy chain 11, smooth muscle
MYRF myelin regulatory factor
PCP4 Purkinje cell protein 4
PLN phospholamban
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
SOX4 SRY (sex determining region Y)-box 4