BRD-K66254772_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K66254772_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
BLNK B-cell linker
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CCL5 chemokine (C-C motif) ligand 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL4A5 collagen, type IV, alpha 5
CRABP1 cellular retinoic acid binding protein 1
ELF4 E74-like factor 4 (ets domain transcription factor)
FBLN1 fibulin 1
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD10 frizzled class receptor 10
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GNAS GNAS complex locus
GPM6B glycoprotein M6B
GRN granulin
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
ITPKB inositol-trisphosphate 3-kinase B
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LYPD3 LY6/PLAUR domain containing 3
MECOM MDS1 and EVI1 complex locus
NAV2 neuron navigator 2
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLXNA1 plexin A1
PRRC2C proline-rich coiled-coil 2C
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RUNX3 runt-related transcription factor 3
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SRRM2 serine/arginine repetitive matrix 2
STOM stomatin
TACC2 transforming, acidic coiled-coil containing protein 2
TOB1 transducer of ERBB2, 1
TOP1 topoisomerase (DNA) I
TRIM29 tripartite motif containing 29
TRPS1 trichorhinophalangeal syndrome I
WT1 Wilms tumor 1

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
ALCAM activated leukocyte cell adhesion molecule
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BGN biglycan
CCDC85B coiled-coil domain containing 85B
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
COL1A2 collagen, type I, alpha 2
COX11 COX11 cytochrome c oxidase copper chaperone
CPB1 carboxypeptidase B1 (tissue)
CRIP1 cysteine-rich protein 1 (intestinal)
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
ELP5 elongator acetyltransferase complex subunit 5
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F12 coagulation factor XII (Hageman factor)
FIBP fibroblast growth factor (acidic) intracellular binding protein
FXYD2 FXYD domain containing ion transport regulator 2
GOLT1B golgi transport 1B
GTPBP8 GTP-binding protein 8 (putative)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
INSIG1 insulin induced gene 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LAMP5 lysosomal-associated membrane protein family, member 5
LIG1 ligase I, DNA, ATP-dependent
MAGED1 melanoma antigen family D1
METRN meteorin, glial cell differentiation regulator
MYH10 myosin, heavy chain 10, non-muscle
NDN necdin, melanoma antigen (MAGE) family member
NNMT nicotinamide N-methyltransferase
PCCB propionyl CoA carboxylase, beta polypeptide
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PGK1 phosphoglycerate kinase 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PROS1 protein S (alpha)
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSPH phosphoserine phosphatase
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPA3 replication protein A3, 14kDa
RPL26L1 ribosomal protein L26-like 1
SATB1 SATB homeobox 1
SIVA1 SIVA1, apoptosis-inducing factor
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPAG4 sperm associated antigen 4
SRI sorcin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STMN1 stathmin 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TPM1 tropomyosin 1 (alpha)
TSPAN13 tetraspanin 13
VCAN versican
WBP5 WW domain binding protein 5
WDR61 WD repeat domain 61
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)