BRD-K66032149_VU0365117-1_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K66032149_VU0365117-1_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CDC25B cell division cycle 25B
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
GTSE1 G-2 and S-phase expressed 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF5B kinesin family member 5B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIMCH1 LIM and calponin homology domains 1
MKI67 marker of proliferation Ki-67
MTF2 metal response element binding transcription factor 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
PBK PDZ binding kinase
PSRC1 proline/serine-rich coiled-coil 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
CA2 carbonic anhydrase II
CD59 CD59 molecule, complement regulatory protein
CP ceruloplasmin (ferroxidase)
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS9 dehydrogenase/reductase (SDR family) member 9
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
FCGBP Fc fragment of IgG binding protein
LTF lactotransferrin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYC v-myc avian myelocytomatosis viral oncogene homolog
NMB neuromedin B
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SST somatostatin
SUB1 SUB1 homolog (S. cerevisiae)
TMEM231 transmembrane protein 231
TSPAN3 tetraspanin 3
WFDC2 WAP four-disulfide core domain 2