BRD-K65983740_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K65983740_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
AKR1C1 aldo-keto reductase family 1, member C1
ATF3 activating transcription factor 3
CALD1 caldesmon 1
CCND2 cyclin D2
CD24 CD24 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CNN3 calponin 3, acidic
CPE carboxypeptidase E
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
FAM129A family with sequence similarity 129, member A
G0S2 G0/G1 switch 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HEBP2 heme binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IGFBP5 insulin-like growth factor binding protein 5
ITGA6 integrin, alpha 6
KLF6 Kruppel-like factor 6
LYZ lysozyme
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE9A phosphodiesterase 9A
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PROS1 protein S (alpha)
RGCC regulator of cell cycle
SCG5 secretogranin V
SYT1 synaptotagmin I
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
C2CD5 C2 calcium-dependent domain containing 5
CCNF cyclin F
CDC20 cell division cycle 20
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CLDN10 claudin 10
CLINT1 clathrin interactor 1
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
ETNK1 ethanolamine kinase 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
HN1 hematological and neurological expressed 1
IRS2 insulin receptor substrate 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF10 Kruppel-like factor 10
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
MRPS2 mitochondrial ribosomal protein S2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
NUP85 nucleoporin 85kDa
PCDH9 protocadherin 9
PLAC8 placenta-specific 8
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLSCR4 phospholipid scramblase 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNX10 sorting nexin 10
SOX11 SRY (sex determining region Y)-box 11
SRPX sushi-repeat containing protein, X-linked
TBC1D31 TBC1 domain family, member 31
TBX2 T-box 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
XYLT1 xylosyltransferase I