BRD-K65983740_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K65983740_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
AREG amphiregulin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCNG1 cyclin G1
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
DDIT4 DNA-damage-inducible transcript 4
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
FCGBP Fc fragment of IgG binding protein
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GSN gelsolin
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
KLF6 Kruppel-like factor 6
KRT20 keratin 20, type I
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OBSL1 obscurin-like 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAP1GAP RAP1 GTPase activating protein
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TBX3 T-box 3
TP53 tumor protein p53
WDR45 WD repeat domain 45
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AKAP7 A kinase (PRKA) anchor protein 7
ARMT1 acidic residue methyltransferase 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BAG3 BCL2-associated athanogene 3
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CFAP20 cilia and flagella associated protein 20
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
ETNK1 ethanolamine kinase 1
EXO1 exonuclease 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ISOC1 isochorismatase domain containing 1
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NPY neuropeptide Y
NT5DC2 5'-nucleotidase domain containing 2
NUP98 nucleoporin 98kDa
PBK PDZ binding kinase
PGC progastricsin (pepsinogen C)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
SHCBP1 SHC SH2-domain binding protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
TARP TCR gamma alternate reading frame protein
TMED2 transmembrane emp24 domain trafficking protein 2
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein