BRD-K65955264_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K65955264_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGAP29 Rho GTPase activating protein 29
ASL argininosuccinate lyase
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
CBS cystathionine-beta-synthase
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL9A3 collagen, type IX, alpha 3
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CTTN cortactin
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
EGR1 early growth response 1
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GMDS GDP-mannose 4,6-dehydratase
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ISG15 ISG15 ubiquitin-like modifier
KCTD5 potassium channel tetramerization domain containing 5
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
LGALS1 lectin, galactoside-binding, soluble, 1
LRMP lymphoid-restricted membrane protein
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MT1F metallothionein 1F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
OBSL1 obscurin-like 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLAU plasminogen activator, urokinase
PLXNB2 plexin B2
PNKP polynucleotide kinase 3'-phosphatase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SDF2L1 stromal cell-derived factor 2-like 1
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLPI secretory leukocyte peptidase inhibitor
SRRM2 serine/arginine repetitive matrix 2
STK38L serine/threonine kinase 38 like
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TJP2 tight junction protein 2
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
UVRAG UV radiation resistance associated
VCAM1 vascular cell adhesion molecule 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ARL4C ADP-ribosylation factor-like 4C
ATF5 activating transcription factor 5
AVL9 AVL9 homolog (S. cerevisiase)
BLCAP bladder cancer associated protein
C14ORF132 chromosome 14 open reading frame 132
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNB1 cyclin B1
CCND2 cyclin D2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CHL1 cell adhesion molecule L1-like
CIAPIN1 cytokine induced apoptosis inhibitor 1
COL5A1 collagen, type V, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSZ cathepsin Z
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DUSP14 dual specificity phosphatase 14
EDNRB endothelin receptor type B
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FGF13 fibroblast growth factor 13
FLRT2 fibronectin leucine rich transmembrane protein 2
FZD7 frizzled class receptor 7
GLUL glutamate-ammonia ligase
HACD3 3-hydroxyacyl-CoA dehydratase 3
IL32 interleukin 32
ITGA6 integrin, alpha 6
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NCOA2 nuclear receptor coactivator 2
NRCAM neuronal cell adhesion molecule
NSG1 neuron specific gene family member 1
PDE10A phosphodiesterase 10A
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLXNC1 plexin C1
RBM34 RNA binding motif protein 34
RBP1 retinol binding protein 1, cellular
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RPL37A ribosomal protein L37a
RYK receptor-like tyrosine kinase
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCARB2 scavenger receptor class B, member 2
SETBP1 SET binding protein 1
SIRPA signal-regulatory protein alpha
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX11 SRY (sex determining region Y)-box 11
STAB1 stabilin 1
SYNRG synergin, gamma
TMEM2 transmembrane protein 2
TRIB2 tribbles pseudokinase 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE3C ubiquitin protein ligase E3C
VCAN versican
WSB2 WD repeat and SOCS box containing 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon