BRD-K65904652_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K65904652_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ARG2 arginase 2
BGN biglycan
BMP4 bone morphogenetic protein 4
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CFD complement factor D (adipsin)
CHMP4A charged multivesicular body protein 4A
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CRABP2 cellular retinoic acid binding protein 2
CTBP2 C-terminal binding protein 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR2 fibroblast growth factor receptor 2
FXYD5 FXYD domain containing ion transport regulator 5
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GREM1 gremlin 1, DAN family BMP antagonist
H1F0 H1 histone family, member 0
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
ITM2C integral membrane protein 2C
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MMD monocyte to macrophage differentiation-associated
NEFL neurofilament, light polypeptide
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
NTS neurotensin
OSBPL10 oxysterol binding protein-like 10
PCP4 Purkinje cell protein 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLIN2 perilipin 2
PLXND1 plexin D1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCH protein kinase C, eta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS10 regulator of G-protein signaling 10
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SPON1 spondin 1, extracellular matrix protein
SYT1 synaptotagmin I
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TPD52L1 tumor protein D52-like 1
TPK1 thiamin pyrophosphokinase 1
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13

decreased expression

Symbol Name
BST2 bone marrow stromal cell antigen 2
CCND1 cyclin D1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DMD dystrophin
DSP desmoplakin
EGR3 early growth response 3
F3 coagulation factor III (thromboplastin, tissue factor)
G0S2 G0/G1 switch 2
IL1RN interleukin 1 receptor antagonist
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LARP1 La ribonucleoprotein domain family, member 1
LPL lipoprotein lipase
LTBP1 latent transforming growth factor beta binding protein 1
MACF1 microtubule-actin crosslinking factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PRDX4 peroxiredoxin 4
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A2 S100 calcium binding protein A2
SPRR1B small proline-rich protein 1B
TKTL1 transketolase-like 1
TNS1 tensin 1
TNS3 tensin 3
TSPAN8 tetraspanin 8