BRD-K65814004_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K65814004_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AIM1 absent in melanoma 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASCC3 activating signal cointegrator 1 complex subunit 3
AZU1 azurocidin 1
BAX BCL2-associated X protein
BLNK B-cell linker
BTG2 BTG family, member 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLCA1 chloride channel accessory 1
COL4A5 collagen, type IV, alpha 5
CPNE3 copine III
DUOX2 dual oxidase 2
FAM198B family with sequence similarity 198, member B
FHOD3 formin homology 2 domain containing 3
FOSL1 FOS-like antigen 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GADD45A growth arrest and DNA-damage-inducible, alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
IRS1 insulin receptor substrate 1
JAG1 jagged 1
JUP junction plakoglobin
KRT20 keratin 20, type I
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
MAOA monoamine oxidase A
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MUC2 mucin 2, oligomeric mucus/gel-forming
MYOF myoferlin
NCF2 neutrophil cytosolic factor 2
OLFM4 olfactomedin 4
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PLAT plasminogen activator, tissue
PRKCI protein kinase C, iota
PRKX protein kinase, X-linked
PRTN3 proteinase 3
PXN paxillin
PYCARD PYD and CARD domain containing
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCPEP1 serine carboxypeptidase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAI2 snail family zinc finger 2
SPINK4 serine peptidase inhibitor, Kazal type 4
STC1 stanniocalcin 1
SUSD4 sushi domain containing 4
TBX3 T-box 3
TBXA2R thromboxane A2 receptor
THBS1 thrombospondin 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
WARS tryptophanyl-tRNA synthetase
WFDC1 WAP four-disulfide core domain 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BZW1 basic leucine zipper and W2 domains 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CIT citron rho-interacting serine/threonine kinase
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CSRP1 cysteine and glycine-rich protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DYNLL1 dynein, light chain, LC8-type 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FKBP11 FK506 binding protein 11, 19 kDa
FSTL1 follistatin-like 1
FUS FUS RNA binding protein
GNAS GNAS complex locus
GOLGA7 golgin A7
GRB14 growth factor receptor-bound protein 14
HMGB3 high mobility group box 3
HNRNPR heterogeneous nuclear ribonucleoprotein R
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB1BP1 integrin beta 1 binding protein 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNB1 karyopherin (importin) beta 1
KRT7 keratin 7, type II
LEPR leptin receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MSH6 mutS homolog 6
NAP1L1 nucleosome assembly protein 1-like 1
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP210 nucleoporin 210kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCDH9 protocadherin 9
PDLIM2 PDZ and LIM domain 2 (mystique)
PHGDH phosphoglycerate dehydrogenase
PLA2G15 phospholipase A2, group XV
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRAME preferentially expressed antigen in melanoma
PRDX1 peroxiredoxin 1
PRDX4 peroxiredoxin 4
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSPH phosphoserine phosphatase
PTMA prothymosin, alpha
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PXMP2 peroxisomal membrane protein 2, 22kDa
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RPN2 ribophorin II
RPS11 ribosomal protein S11
SEPHS1 selenophosphate synthetase 1
SERBP1 SERPINE1 mRNA binding protein 1
SET SET nuclear proto-oncogene
SORBS3 sorbin and SH3 domain containing 3
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMELESS timeless circadian clock
TMPO thymopoietin
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM1 translocation associated membrane protein 1
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZNF22 zinc finger protein 22