BRD-K65503129_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K65503129_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACBD3 acyl-CoA binding domain containing 3
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKAP9 A kinase (PRKA) anchor protein 9
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CAB39 calcium binding protein 39
CALCOCO2 calcium binding and coiled-coil domain 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLIC4 chloride intracellular channel 4
COMP cartilage oligomeric matrix protein
CTTN cortactin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FXR1 fragile X mental retardation, autosomal homolog 1
GAS6 growth arrest-specific 6
GULP1 GULP, engulfment adaptor PTB domain containing 1
HECA headcase homolog (Drosophila)
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI27 interferon, alpha-inducible protein 27
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IPO13 importin 13
JMJD6 jumonji domain containing 6
KIAA0930 KIAA0930
KLHL9 kelch-like family member 9
LTBP2 latent transforming growth factor beta binding protein 2
LUM lumican
MAP7 microtubule-associated protein 7
MMP12 matrix metallopeptidase 12
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO1D myosin ID
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPOLA poly(A) polymerase alpha
PERP PERP, TP53 apoptosis effector
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSAT1 phosphoserine aminotransferase 1
RND3 Rho family GTPase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SH3BP4 SH3-domain binding protein 4
SORBS2 sorbin and SH3 domain containing 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STC2 stanniocalcin 2
SULF1 sulfatase 1
TMEM45A transmembrane protein 45A
TRIM2 tripartite motif containing 2
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIPOQ adiponectin, C1Q and collagen domain containing
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
APOD apolipoprotein D
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
C7 complement component 7
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHRDL1 chordin-like 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CNPY3 canopy FGF signaling regulator 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DES desmin
DHRS2 dehydrogenase/reductase (SDR family) member 2
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GNAS GNAS complex locus
GPC3 glypican 3
GRWD1 glutamate-rich WD repeat containing 1
HNMT histamine N-methyltransferase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
INSIG1 insulin induced gene 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD12 potassium channel tetramerization domain containing 12
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LPAR6 lysophosphatidic acid receptor 6
LPL lipoprotein lipase
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NID1 nidogen 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAC8 placenta-specific 8
PLN phospholamban
PPA1 pyrophosphatase (inorganic) 1
PTN pleiotrophin
RDX radixin
RGS10 regulator of G-protein signaling 10
RPL37A ribosomal protein L37a
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A11 S100 calcium binding protein A11
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SOBP sine oculis binding protein homolog (Drosophila)
SORBS1 sorbin and SH3 domain containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
ZFP36L1 ZFP36 ring finger protein-like 1