BRD-K65417056_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K65417056_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ALB albumin
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGAP29 Rho GTPase activating protein 29
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
BPHL biphenyl hydrolase-like (serine hydrolase)
CA2 carbonic anhydrase II
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD9 CD9 molecule
CEP57 centrosomal protein 57kDa
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
F11R F11 receptor
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FRZB frizzled-related protein
FST follistatin
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
GAS6 growth arrest-specific 6
GDF3 growth differentiation factor 3
GPER1 G protein-coupled estrogen receptor 1
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H4C histone cluster 1, H4c
HPGDS hematopoietic prostaglandin D synthase
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
IPO13 importin 13
IRF6 interferon regulatory factor 6
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KRT19 keratin 19, type I
LPAR6 lysophosphatidic acid receptor 6
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MKNK1 MAP kinase interacting serine/threonine kinase 1
MT1F metallothionein 1F
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NOS3 nitric oxide synthase 3 (endothelial cell)
NVL nuclear VCP-like
PAH phenylalanine hydroxylase
PAPD7 PAP associated domain containing 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PMM2 phosphomannomutase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A14 S100 calcium binding protein A14
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC38A1 solute carrier family 38, member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TF transferrin
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM30B transmembrane protein 30B
TPD52 tumor protein D52
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF395 zinc finger protein 395
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASXL2 additional sex combs like transcriptional regulator 2
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CLINT1 clathrin interactor 1
COCH cochlin
CST3 cystatin C
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
EDNRB endothelin receptor type B
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP11 FK506 binding protein 11, 19 kDa
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GOLM1 golgi membrane protein 1
GRAMD1B GRAM domain containing 1B
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HBB hemoglobin, beta
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLTF helicase-like transcription factor
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXC6 homeobox C6
IL6ST interleukin 6 signal transducer
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LEPR leptin receptor
LTBP3 latent transforming growth factor beta binding protein 3
MAGED1 melanoma antigen family D1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MID1 midline 1
MSRB2 methionine sulfoxide reductase B2
MSX1 msh homeobox 1
NAAA N-acylethanolamine acid amidase
NAV3 neuron navigator 3
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NUP210 nucleoporin 210kDa
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PRAME preferentially expressed antigen in melanoma
PSPH phosphoserine phosphatase
PTGES prostaglandin E synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SACS sacsin molecular chaperone
SECISBP2L SECIS binding protein 2-like
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SMC1A structural maintenance of chromosomes 1A
SORD sorbitol dehydrogenase
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TOP2B topoisomerase (DNA) II beta 180kDa
TSPAN8 tetraspanin 8
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
ZBTB38 zinc finger and BTB domain containing 38