BRD-K65404805_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K65404805_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM19 ADAM metallopeptidase domain 19
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA6 annexin A6
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CAPG capping protein (actin filament), gelsolin-like
CHRDL1 chordin-like 1
CKB creatine kinase, brain
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
EDN3 endothelin 3
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
F12 coagulation factor XII (Hageman factor)
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FCMR Fc fragment of IgM receptor
FXYD6 FXYD domain containing ion transport regulator 6
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTA4 glutathione S-transferase alpha 4
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
MAOB monoamine oxidase B
MATN2 matrilin 2
MGST3 microsomal glutathione S-transferase 3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
MTSS1 metastasis suppressor 1
NES nestin
OLFM1 olfactomedin 1
PALLD palladin, cytoskeletal associated protein
PCGF2 polycomb group ring finger 2
PTN pleiotrophin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS10 regulator of G-protein signaling 10
RNASE4 ribonuclease, RNase A family, 4
RTN1 reticulon 1
RTN2 reticulon 2
S100A11 S100 calcium binding protein A11
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
STMN2 stathmin 2
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
UGCG UDP-glucose ceramide glucosyltransferase
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
DAPK1 death-associated protein kinase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DSP desmoplakin
EIF5 eukaryotic translation initiation factor 5
FST follistatin
GAREM GRB2 associated, regulator of MAPK1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GRWD1 glutamate-rich WD repeat containing 1
HIST1H2BG histone cluster 1, H2bg
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
IGL immunoglobulin lambda locus
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
ODC1 ornithine decarboxylase 1
PCDH9 protocadherin 9
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PRKD3 protein kinase D3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SDC1 syndecan 1
SFN stratifin
SLC38A1 solute carrier family 38, member 1
SULF1 sulfatase 1
TARDBP TAR DNA binding protein
TFRC transferrin receptor
THBS1 thrombospondin 1
UBXN8 UBX domain protein 8