BRD-K65242613_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K65242613_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
AEBP1 AE binding protein 1
ANOS1 anosmin 1
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AREG amphiregulin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CBS cystathionine-beta-synthase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD163 CD163 molecule
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLC Charcot-Leyden crystal galectin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
ELANE elastase, neutrophil expressed
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FOSL1 FOS-like antigen 1
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA6 integrin, alpha 6
KRT7 keratin 7, type II
LPIN1 lipin 1
LPL lipoprotein lipase
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MTUS1 microtubule associated tumor suppressor 1
OLFM4 olfactomedin 4
PAWR PRKC, apoptosis, WT1, regulator
PCDH9 protocadherin 9
PELI1 pellino E3 ubiquitin protein ligase 1
PPARG peroxisome proliferator-activated receptor gamma
RBMS1 RNA binding motif, single stranded interacting protein 1
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
TAGLN transgelin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM1 tropomyosin 1 (alpha)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)

decreased expression

Symbol Name
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
ARMCX6 armadillo repeat containing, X-linked 6
ATP9A ATPase, class II, type 9A
C1ORF54 chromosome 1 open reading frame 54
C2CD5 C2 calcium-dependent domain containing 5
CCNF cyclin F
CD81 CD81 molecule
CDCA4 cell division cycle associated 4
CDK4 cyclin-dependent kinase 4
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CTSH cathepsin H
DEGS1 delta(4)-desaturase, sphingolipid 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4A3 eukaryotic translation initiation factor 4A3
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GATA3 GATA binding protein 3
GNPDA1 glucosamine-6-phosphate deaminase 1
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
KCTD12 potassium channel tetramerization domain containing 12
LOC100272216 uncharacterized LOC100272216
LPCAT1 lysophosphatidylcholine acyltransferase 1
MELK maternal embryonic leucine zipper kinase
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
RAB20 RAB20, member RAS oncogene family
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMC1A structural maintenance of chromosomes 1A
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TFPI2 tissue factor pathway inhibitor 2
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC4 trafficking protein particle complex 4
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
XIST X inactive specific transcript (non-protein coding)