BRD-K65182930_NVP-AUY922_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K65182930_NVP-AUY922_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAG3 BCL2-associated athanogene 3
C10ORF10 chromosome 10 open reading frame 10
CACYBP calcyclin binding protein
CBS cystathionine-beta-synthase
CDK5RAP3 CDK5 regulatory subunit associated protein 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
HIST1H2BG histone cluster 1, H2bg
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
LAPTM4B lysosomal protein transmembrane 4 beta
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PDZK1 PDZ domain containing 1
PRKX protein kinase, X-linked
RGS1 regulator of G-protein signaling 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TSPAN13 tetraspanin 13

decreased expression

Symbol Name
APOD apolipoprotein D
AREG amphiregulin
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BASP1 brain abundant, membrane attached signal protein 1
CA2 carbonic anhydrase II
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CDK14 cyclin-dependent kinase 14
CH25H cholesterol 25-hydroxylase
CST3 cystatin C
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
FAP fibroblast activation protein, alpha
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FGF13 fibroblast growth factor 13
FXYD3 FXYD domain containing ion transport regulator 3
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HIRA histone cell cycle regulator
HNRNPL heterogeneous nuclear ribonucleoprotein L
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
KLF4 Kruppel-like factor 4 (gut)
LTF lactotransferrin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLAGL1 pleiomorphic adenoma gene-like 1
POSTN periostin, osteoblast specific factor
REEP1 receptor accessory protein 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPP1 secreted phosphoprotein 1
SRSF6 serine/arginine-rich splicing factor 6
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPD52L2 tumor protein D52-like 2
TRIB2 tribbles pseudokinase 2
VCAN versican