BRD-K65182930_NVP-AUY922_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K65182930_NVP-AUY922_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSM3 acyl-CoA synthetase medium-chain family member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOB aldolase B, fructose-bisphosphate
ANXA4 annexin A4
APOE apolipoprotein E
BAG3 BCL2-associated athanogene 3
C6ORF48 chromosome 6 open reading frame 48
CA2 carbonic anhydrase II
CAPN6 calpain 6
CCNG1 cyclin G1
CGA glycoprotein hormones, alpha polypeptide
COBL cordon-bleu WH2 repeat protein
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPVL carboxypeptidase, vitellogenic-like
CRYAB crystallin, alpha B
CRYZ crystallin, zeta (quinone reductase)
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
EGR1 early growth response 1
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4A2 eukaryotic translation initiation factor 4A2
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FGF13 fibroblast growth factor 13
FMO3 flavin containing monooxygenase 3
FOLR1 folate receptor 1 (adult)
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD2 FXYD domain containing ion transport regulator 2
GPNMB glycoprotein (transmembrane) nmb
GRAMD1C GRAM domain containing 1C
GRB14 growth factor receptor-bound protein 14
HIST1H2BG histone cluster 1, H2bg
HOXC6 homeobox C6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JUP junction plakoglobin
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
LAMP2 lysosomal-associated membrane protein 2
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LOC100505650 uncharacterized LOC100505650
METTL7A methyltransferase like 7A
N4BP2L2 NEDD4 binding protein 2-like 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NR2F2 nuclear receptor subfamily 2, group F, member 2
OBSL1 obscurin-like 1
OGDHL oxoglutarate dehydrogenase-like
OLFML3 olfactomedin-like 3
PCBP2 poly(rC) binding protein 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLAGL1 pleiomorphic adenoma gene-like 1
PLLP plasmolipin
PPID peptidylprolyl isomerase D
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRODH proline dehydrogenase (oxidase) 1
PROM1 prominin 1
PTEN phosphatase and tensin homolog
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAD Ras-related associated with diabetes
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
TOB1 transducer of ERBB2, 1
TOMM34 translocase of outer mitochondrial membrane 34
TSC22D1 TSC22 domain family, member 1
TWF1 twinfilin actin binding protein 1
TXNIP thioredoxin interacting protein
UBQLN2 ubiquilin 2
VAV3 vav 3 guanine nucleotide exchange factor
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACAT2 acetyl-CoA acetyltransferase 2
ACSL5 acyl-CoA synthetase long-chain family member 5
AKAP1 A kinase (PRKA) anchor protein 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
C3ORF14 chromosome 3 open reading frame 14
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCNE2 cyclin E2
CD52 CD52 molecule
CD9 CD9 molecule
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CETN3 centrin, EF-hand protein, 3
CHIC2 cysteine-rich hydrophobic domain 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CORO1A coronin, actin binding protein, 1A
CREB1 cAMP responsive element binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FRZB frizzled-related protein
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HOPX HOP homeobox
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFI44L interferon-induced protein 44-like
IGKC immunoglobulin kappa constant
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
KRT6B keratin 6B, type II
LAPTM5 lysosomal protein transmembrane 5
LMO3 LIM domain only 3 (rhombotin-like 2)
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMD monocyte to macrophage differentiation-associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
NRGN neurogranin (protein kinase C substrate, RC3)
NUP85 nucleoporin 85kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51C RAD51 paralog C
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
S100A2 S100 calcium binding protein A2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC43A3 solute carrier family 43, member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
SULF1 sulfatase 1
TAGLN transgelin
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TRIB3 tribbles pseudokinase 3
TYMP thymidine phosphorylase
ZFP36L2 ZFP36 ring finger protein-like 2