BRD-K65182930_NVP-AUY922_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K65182930_NVP-AUY922_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY9 adenylate cyclase 9
AFF1 AF4/FMR2 family, member 1
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL4A2 collagen, type IV, alpha 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFCAB14 EF-hand calcium binding domain 14
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FUCA1 fucosidase, alpha-L- 1, tissue
FXR1 fragile X mental retardation, autosomal homolog 1
GOLM1 golgi membrane protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-E major histocompatibility complex, class I, E
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IGFBP7 insulin-like growth factor binding protein 7
KLHDC10 kelch domain containing 10
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NNMT nicotinamide N-methyltransferase
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
OLFML2B olfactomedin-like 2B
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE4D phosphodiesterase 4D, cAMP-specific
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SDC2 syndecan 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SMNDC1 survival motor neuron domain containing 1
STOM stomatin
TBC1D4 TBC1 domain family, member 4
TMEM2 transmembrane protein 2
TRAC T cell receptor alpha constant

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANPEP alanyl (membrane) aminopeptidase
ASPH aspartate beta-hydroxylase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF61 chromosome 1 open reading frame 61
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CCDC85B coiled-coil domain containing 85B
CCNE2 cyclin E2
CCP110 centriolar coiled coil protein 110kDa
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CLEC7A C-type lectin domain family 7, member A
CSTA cystatin A (stefin A)
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDB2 damage-specific DNA binding protein 2, 48kDa
DPY19L2P2 DPY19L2 pseudogene 2
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EREG epiregulin
ETV1 ets variant 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
G0S2 G0/G1 switch 2
GATA6 GATA binding protein 6
GSTA4 glutathione S-transferase alpha 4
H1F0 H1 histone family, member 0
HDAC9 histone deacetylase 9
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1B interleukin 1, beta
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
MAN1A1 mannosidase, alpha, class 1A, member 1
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MNDA myeloid cell nuclear differentiation antigen
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
NCF2 neutrophil cytosolic factor 2
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
PAQR4 progestin and adipoQ receptor family member IV
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKL phosphofructokinase, liver
PLAU plasminogen activator, urokinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEK pleckstrin
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
S100A9 S100 calcium binding protein A9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPAG4 sperm associated antigen 4
SRI sorcin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TMEM251 transmembrane protein 251
TMEM45A transmembrane protein 45A
TMEM5 transmembrane protein 5
UBE2E3 ubiquitin-conjugating enzyme E2E 3
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