BRD-K65182930_NVP-AUY922_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K65182930_NVP-AUY922_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADGRG6 adhesion G protein-coupled receptor G6
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCNG1 cyclin G1
CRYZ crystallin, zeta (quinone reductase)
DAAM2 dishevelled associated activator of morphogenesis 2
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
EIF4B eukaryotic translation initiation factor 4B
FAM63A family with sequence similarity 63, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FTH1 ferritin, heavy polypeptide 1
GREB1 growth regulation by estrogen in breast cancer 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
INSR insulin receptor
ITPKB inositol-trisphosphate 3-kinase B
JMJD6 jumonji domain containing 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT19 keratin 19, type I
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MSMO1 methylsterol monooxygenase 1
MYL9 myosin, light chain 9, regulatory
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PRAME preferentially expressed antigen in melanoma
QPRT quinolinate phosphoribosyltransferase
RPL31 ribosomal protein L31
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SQLE squalene epoxidase
SULF1 sulfatase 1
TPD52L1 tumor protein D52-like 1
TWIST1 twist family bHLH transcription factor 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ASPH aspartate beta-hydroxylase
AXL AXL receptor tyrosine kinase
CD58 CD58 molecule
CDCP1 CUB domain containing protein 1
CKLF chemokine-like factor
CLCA2 chloride channel accessory 2
CLEC2B C-type lectin domain family 2, member B
CLGN calmegin
CTGF connective tissue growth factor
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HBEGF heparin-binding EGF-like growth factor
HPCAL1 hippocalcin-like 1
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
KRT6B keratin 6B, type II
MAP1B microtubule-associated protein 1B
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYO10 myosin X
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS2 protease, serine, 2 (trypsin 2)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SDC1 syndecan 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPHK1 sphingosine kinase 1
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STEAP3 STEAP family member 3, metalloreductase
TACSTD2 tumor-associated calcium signal transducer 2
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UPP1 uridine phosphorylase 1