BRD-K65182930_NVP-AUY922_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K65182930_NVP-AUY922_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADA adenosine deaminase
ADAM10 ADAM metallopeptidase domain 10
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG6 adhesion G protein-coupled receptor G6
ANOS1 anosmin 1
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
BRD8 bromodomain containing 8
BST2 bone marrow stromal cell antigen 2
C1ORF115 chromosome 1 open reading frame 115
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNG1 cyclin G1
CFB complement factor B
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CRYZ crystallin, zeta (quinone reductase)
CTSH cathepsin H
DAPK1 death-associated protein kinase 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EPAS1 endothelial PAS domain protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FBLN1 fibulin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FTH1 ferritin, heavy polypeptide 1
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GPC3 glypican 3
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF2C kinesin family member 2C
KRT14 keratin 14, type I
LCN2 lipocalin 2
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAGEH1 melanoma antigen family H1
MAN2A1 mannosidase, alpha, class 2A, member 1
MKL2 MKL/myocardin-like 2
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
MYRF myelin regulatory factor
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NISCH nischarin
NUCB2 nucleobindin 2
NXN nucleoredoxin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDZK1IP1 PDZK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RPL31 ribosomal protein L31
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIDT2 SID1 transmembrane family, member 2
SIK1 salt-inducible kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SORD sorbitol dehydrogenase
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON2 spondin 2, extracellular matrix protein
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SQLE squalene epoxidase
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
VNN1 vanin 1
WFS1 Wolfram syndrome 1 (wolframin)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APLP2 amyloid beta (A4) precursor-like protein 2
AXL AXL receptor tyrosine kinase
BIRC2 baculoviral IAP repeat containing 2
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CD3EAP CD3e molecule, epsilon associated protein
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDC25A cell division cycle 25A
CEP170 centrosomal protein 170kDa
CKLF chemokine-like factor
CLC Charcot-Leyden crystal galectin
COTL1 coactosin-like F-actin binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDB2 damage-specific DNA binding protein 2, 48kDa
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
EPN2 epsin 2
EREG epiregulin
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HBEGF heparin-binding EGF-like growth factor
HMGA1 high mobility group AT-hook 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
INHBA inhibin, beta A
LIF leukemia inhibitory factor
MAP1B microtubule-associated protein 1B
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MCUR1 mitochondrial calcium uniporter regulator 1
MTCH2 mitochondrial carrier 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTSS1 metastasis suppressor 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO10 myosin X
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPF4 pre-mRNA processing factor 4
RFC2 replication factor C (activator 1) 2, 40kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TFDP1 transcription factor Dp-1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
UNG uracil-DNA glycosylase
VCAN versican
WSB2 WD repeat and SOCS box containing 2
ZFP36L1 ZFP36 ring finger protein-like 1