BRD-K65182930_NVP-AUY922_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

259 genes differentially expressed following the BRD-K65182930_NVP-AUY922_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ADI1 acireductone dioxygenase 1
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
AKAP9 A kinase (PRKA) anchor protein 9
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX1 armadillo repeat containing, X-linked 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF115 chromosome 1 open reading frame 115
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C8ORF4 chromosome 8 open reading frame 4
CCDC28A coiled-coil domain containing 28A
CCNG1 cyclin G1
CCNG2 cyclin G2
CD163 CD163 molecule
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
CDH3 cadherin 3, type 1, P-cadherin (placental)
CES1 carboxylesterase 1
CGA glycoprotein hormones, alpha polypeptide
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CRYZ crystallin, zeta (quinone reductase)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFCAB14 EF-hand calcium binding domain 14
EPCAM epithelial cell adhesion molecule
ERBB4 erb-b2 receptor tyrosine kinase 4
FADS1 fatty acid desaturase 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA2 GATA binding protein 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLRX glutaredoxin (thioltransferase)
GOLGB1 golgin B1
GOLPH3L golgi phosphoprotein 3-like
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HOXA5 homeobox A5
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
LDHB lactate dehydrogenase B
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LXN latexin
MAOA monoamine oxidase A
MAP2K6 mitogen-activated protein kinase kinase 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFE2L1 nuclear factor, erythroid 2-like 1
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
NUCB2 nucleobindin 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PLD3 phospholipase D family, member 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RAB17 RAB17, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SGCE sarcoglycan, epsilon
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORBS3 sorbin and SH3 domain containing 3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STC1 stanniocalcin 1
STOM stomatin
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THSD7A thrombospondin, type I, domain containing 7A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ACTB actin, beta
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
C1ORF116 chromosome 1 open reading frame 116
C20ORF27 chromosome 20 open reading frame 27
CA2 carbonic anhydrase II
CCDC85B coiled-coil domain containing 85B
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CENPU centromere protein U
CSTA cystatin A (stefin A)
DESI1 desumoylating isopeptidase 1
DHFR dihydrofolate reductase
DONSON downstream neighbor of SON
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
EGR3 early growth response 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
EXOSC2 exosome component 2
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GYG1 glycogenin 1
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOMER2 homer scaffolding protein 2
HOPX HOP homeobox
IFI44L interferon-induced protein 44-like
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO4 importin 4
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LAGE3 L antigen family, member 3
LOXL1 lysyl oxidase-like 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
METRN meteorin, glial cell differentiation regulator
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NMU neuromedin U
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NXT1 nuclear transport factor 2-like export factor 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEA15 phosphoprotein enriched in astrocytes 15
PGAM1 phosphoglycerate mutase 1 (brain)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
PPA1 pyrophosphatase (inorganic) 1
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF19 pre-mRNA processing factor 19
PRR7 proline rich 7 (synaptic)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
S100A7 S100 calcium binding protein A7
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SRM spermidine synthase
SUB1 SUB1 homolog (S. cerevisiae)
TAGLN transgelin
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPIN TIMELESS interacting protein
TOR3A torsin family 3, member A
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb