BRD-K65182930_NVP-AUY922_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

336 genes differentially expressed following the BRD-K65182930_NVP-AUY922_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACSF2 acyl-CoA synthetase family member 2
ADGRG1 adhesion G protein-coupled receptor G1
AGR2 anterior gradient 2
AKAP9 A kinase (PRKA) anchor protein 9
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF54 chromosome 1 open reading frame 54
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CALCOCO1 calcium binding and coiled-coil domain 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CLEC3B C-type lectin domain family 3, member B
CLIC5 chloride intracellular channel 5
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CTSF cathepsin F
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DEFB1 defensin, beta 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLG5 discs, large homolog 5 (Drosophila)
DNASE2 deoxyribonuclease II, lysosomal
DST dystonin
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EIF4B eukaryotic translation initiation factor 4B
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FBLN2 fibulin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FMO2 flavin containing monooxygenase 2 (non-functional)
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GALC galactosylceramidase
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GSN gelsolin
HBP1 HMG-box transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-E major histocompatibility complex, class I, E
HOXA5 homeobox A5
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL2RB interleukin 2 receptor, beta
INSR insulin receptor
ISYNA1 inositol-3-phosphate synthase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF2C kinesin family member 2C
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMB2 laminin, beta 2 (laminin S)
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LITAF lipopolysaccharide-induced TNF factor
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGED2 melanoma antigen family D2
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MATN2 matrilin 2
METTL7A methyltransferase like 7A
MXD4 MAX dimerization protein 4
MXRA5 matrix-remodelling associated 5
NAV2 neuron navigator 2
NEBL nebulette
NOTCH3 notch 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL9 oxysterol binding protein-like 9
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLXNB2 plexin B2
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
PROS1 protein S (alpha)
PRSS23 protease, serine, 23
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOQ ras homolog family member Q
RND3 Rho family GTPase 3
RPS27L ribosomal protein S27-like
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SKAP2 src kinase associated phosphoprotein 2
SLC16A4 solute carrier family 16, member 4
SLC22A18 solute carrier family 22, member 18
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMA4 glucuronidase, beta pseudogene
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLE2 transducin-like enhancer of split 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP9X ubiquitin specific peptidase 9, X-linked
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BYSL bystin-like
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CRCT1 cysteine-rich C-terminal 1
CTPS1 CTP synthase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EREG epiregulin
EXOSC2 exosome component 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FAM216A family with sequence similarity 216, member A
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HMOX2 heme oxygenase 2
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
IARS isoleucyl-tRNA synthetase
IER2 immediate early response 2
IER3 immediate early response 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INHBA inhibin, beta A
IPO4 importin 4
IPO5 importin 5
LBR lamin B receptor
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MDN1 MDN1, midasin homolog (yeast)
MELK maternal embryonic leucine zipper kinase
MRPL15 mitochondrial ribosomal protein L15
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NAV3 neuron navigator 3
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NDC1 NDC1 transmembrane nucleoporin
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
NUP85 nucleoporin 85kDa
NXT1 nuclear transport factor 2-like export factor 1
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PEA15 phosphoprotein enriched in astrocytes 15
PFAS phosphoribosylformylglycinamidine synthase
PHB prohibitin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PRKCA protein kinase C, alpha
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSPH phosphoserine phosphatase
PTX3 pentraxin 3, long
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SEH1L SEH1-like (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SNAI2 snail family zinc finger 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TEAD4 TEA domain family member 4
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UPP1 uridine phosphorylase 1
VRK1 vaccinia related kinase 1
WDR12 WD repeat domain 12
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36L1 ZFP36 ring finger protein-like 1
ZWINT ZW10 interacting kinetochore protein