BRD-K65182930_NVP-AUY922_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-K65182930_NVP-AUY922_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABI1 abl-interactor 1
ADAM28 ADAM metallopeptidase domain 28
ADAMDEC1 ADAM-like, decysin 1
ADCK3 aarF domain containing kinase 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AQP9 aquaporin 9
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASMTL acetylserotonin O-methyltransferase-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BCL2A1 BCL2-related protein A1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF115 chromosome 1 open reading frame 115
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CFLAR CASP8 and FADD-like apoptosis regulator
CGA glycoprotein hormones, alpha polypeptide
CHPT1 choline phosphotransferase 1
CLDN8 claudin 8
CLEC2B C-type lectin domain family 2, member B
CLSTN1 calsyntenin 1
CLU clusterin
CPVL carboxypeptidase, vitellogenic-like
CSTB cystatin B (stefin B)
CYTH1 cytohesin 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP14 dual specificity phosphatase 14
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EED embryonic ectoderm development
FBXO11 F-box protein 11
FNBP1 formin binding protein 1
FOXJ3 forkhead box J3
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIPK1 homeodomain interacting protein kinase 1
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGLL1 immunoglobulin lambda-like polypeptide 1
IL1R2 interleukin 1 receptor, type II
IL7R interleukin 7 receptor
KIF5B kinesin family member 5B
KLHL24 kelch-like family member 24
LGMN legumain
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MPZL1 myelin protein zero-like 1
MTCH1 mitochondrial carrier 1
MXD4 MAX dimerization protein 4
MYO10 myosin X
MYO5A myosin VA (heavy chain 12, myoxin)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDHX pyruvate dehydrogenase complex, component X
PDLIM1 PDZ and LIM domain 1
PFKL phosphofructokinase, liver
PFN2 profilin 2
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTTG1IP pituitary tumor-transforming 1 interacting protein
QPRT quinolinate phosphoribosyltransferase
RYBP RING1 and YY1 binding protein
SARAF store-operated calcium entry-associated regulatory factor
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERINC3 serine incorporator 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC46A3 solute carrier family 46, member 3
SLIT2 slit homolog 2 (Drosophila)
SOD1 superoxide dismutase 1, soluble
TBC1D4 TBC1 domain family, member 4
TNPO1 transportin 1
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
UGCG UDP-glucose ceramide glucosyltransferase
UGDH UDP-glucose 6-dehydrogenase
USP33 ubiquitin specific peptidase 33
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDR48 WD repeat domain 48
ZDHHC7 zinc finger, DHHC-type containing 7

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C11ORF48
CD200 CD200 molecule
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CHMP4A charged multivesicular body protein 4A
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COA3 cytochrome c oxidase assembly factor 3
CST1 cystatin SN
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DESI1 desumoylating isopeptidase 1
DPH2 DPH2 homolog (S. cerevisiae)
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERGIC2 ERGIC and golgi 2
EXT1 exostosin glycosyltransferase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FANCG Fanconi anemia, complementation group G
FOLR1 folate receptor 1 (adult)
FXYD3 FXYD domain containing ion transport regulator 3
GALE UDP-galactose-4-epimerase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX1 glutathione peroxidase 1
HILPDA hypoxia inducible lipid droplet-associated
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INHBA inhibin, beta A
IPO4 importin 4
KCTD14 potassium channel tetramerization domain containing 14
KRT18 keratin 18, type I
LAMP3 lysosomal-associated membrane protein 3
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
LOC100505650 uncharacterized LOC100505650
LUM lumican
MALL mal, T-cell differentiation protein-like
MEA1 male-enhanced antigen 1
MPV17 MpV17 mitochondrial inner membrane protein
MPZL2 myelin protein zero-like 2
MRPL12 mitochondrial ribosomal protein L12
MRPL24 mitochondrial ribosomal protein L24
MRPL57 mitochondrial ribosomal protein L57
MSLN mesothelin
MSRB1 methionine sulfoxide reductase B1
MX1 MX dynamin-like GTPase 1
NLRP2 NLR family, pyrin domain containing 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUTF2 nuclear transport factor 2
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXLD1 oxidoreductase-like domain containing 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
PREB prolactin regulatory element binding
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCR1 pyrroline-5-carboxylate reductase 1
RECQL RecQ helicase-like
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
S100A6 S100 calcium binding protein A6
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNF8 SNF8, ESCRT-II complex subunit
SPRY4 sprouty homolog 4 (Drosophila)
SPTSSA serine palmitoyltransferase, small subunit A
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STK10 serine/threonine kinase 10
STRA13 stimulated by retinoic acid 13
TAGLN transgelin
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI2 tissue factor pathway inhibitor 2
THTPA thiamine triphosphatase
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM223 transmembrane protein 223
TMEM5 transmembrane protein 5
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TP53I3 tumor protein p53 inducible protein 3
TSPAN5 tetraspanin 5
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE3C ubiquitin protein ligase E3C
VCAN versican
XBP1 X-box binding protein 1
ZNF593 zinc finger protein 593