BRD-K65182930_NVP-AUY922_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-K65182930_NVP-AUY922_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKAP9 A kinase (PRKA) anchor protein 9
AKR1C1 aldo-keto reductase family 1, member C1
AQP1 aquaporin 1 (Colton blood group)
AURKA aurora kinase A
BBX bobby sox homolog (Drosophila)
C1ORF54 chromosome 1 open reading frame 54
C1QB complement component 1, q subcomponent, B chain
C4BPA complement component 4 binding protein, alpha
CCDC28A coiled-coil domain containing 28A
CD14 CD14 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL3A1 collagen, type III, alpha 1
CYB561 cytochrome b561
DAPK1 death-associated protein kinase 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHDDS dehydrodolichyl diphosphate synthase
ECHDC2 enoyl CoA hydratase domain containing 2
EIF4B eukaryotic translation initiation factor 4B
EPAS1 endothelial PAS domain protein 1
EPHA4 EPH receptor A4
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FRY furry homolog (Drosophila)
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GCC2 GRIP and coiled-coil domain containing 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLUL glutamate-ammonia ligase
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
HLA-E major histocompatibility complex, class I, E
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
LDB2 LIM domain binding 2
LITAF lipopolysaccharide-induced TNF factor
LTF lactotransferrin
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
PCDH17 protocadherin 17
PCP4 Purkinje cell protein 4
PCYOX1 prenylcysteine oxidase 1
PFDN5 prefoldin subunit 5
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PROM1 prominin 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAP1GAP RAP1 GTPase activating protein
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMEM97 transmembrane protein 97
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFS1 Wolfram syndrome 1 (wolframin)
YIPF3 Yip1 domain family, member 3
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACOT9 acyl-CoA thioesterase 9
ADAM12 ADAM metallopeptidase domain 12
ADM adrenomedullin
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
ARL4A ADP-ribosylation factor-like 4A
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AXL AXL receptor tyrosine kinase
BIRC2 baculoviral IAP repeat containing 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
CNIH4 cornichon family AMPA receptor auxiliary protein 4
CNN3 calponin 3, acidic
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
FAM216A family with sequence similarity 216, member A
FBN1 fibrillin 1
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGA6 integrin, alpha 6
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGAV integrin, alpha V
JAG1 jagged 1
KLF10 Kruppel-like factor 10
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
MAMLD1 mastermind-like domain containing 1
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MMP3 matrix metallopeptidase 3
MT2A metallothionein 2A
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRG1 neuregulin 1
PALLD palladin, cytoskeletal associated protein
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM2 PDZ and LIM domain 2 (mystique)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRKCA protein kinase C, alpha
PRMT1 protein arginine methyltransferase 1
PTX3 pentraxin 3, long
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
S100A2 S100 calcium binding protein A2
SAMD4A sterile alpha motif domain containing 4A
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TUBB2A tubulin, beta 2A class IIa
UPP1 uridine phosphorylase 1
VCAN versican