BRD-K65182930_NVP-AUY922_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

227 genes differentially expressed following the BRD-K65182930_NVP-AUY922_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AKAP9 A kinase (PRKA) anchor protein 9
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BMP7 bone morphogenetic protein 7
C1ORF54 chromosome 1 open reading frame 54
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CAT catalase
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CES1 carboxylesterase 1
CGA glycoprotein hormones, alpha polypeptide
CLDN8 claudin 8
COBL cordon-bleu WH2 repeat protein
COL2A1 collagen, type II, alpha 1
COL4A1 collagen, type IV, alpha 1
COPA coatomer protein complex, subunit alpha
CRABP1 cellular retinoic acid binding protein 1
CXCL13 chemokine (C-X-C motif) ligand 13
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
EPCAM epithelial cell adhesion molecule
ERGIC3 ERGIC and golgi 3
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGB1 golgin B1
GSTA1 glutathione S-transferase alpha 1
HBP1 HMG-box transcription factor 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IRX5 iroquois homeobox 5
JADE2 jade family PHD finger 2
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LETMD1 LETM1 domain containing 1
LITAF lipopolysaccharide-induced TNF factor
LRRC16A leucine rich repeat containing 16A
MAGED2 melanoma antigen family D2
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP7 microtubule-associated protein 7
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MSMB microseminoprotein, beta-
MYH10 myosin, heavy chain 10, non-muscle
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NKX2-1 NK2 homeobox 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PRUNE prune exopolyphosphatase
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RGS10 regulator of G-protein signaling 10
RPL31 ribosomal protein L31
SEC31A SEC31 homolog A (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SPAG6 sperm associated antigen 6
SPP1 secreted phosphoprotein 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRSF5 serine/arginine-rich splicing factor 5
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAC1 tachykinin, precursor 1
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TP53 tumor protein p53
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
USP9X ubiquitin specific peptidase 9, X-linked
VWA8 von Willebrand factor A domain containing 8
YPEL5 yippee-like 5 (Drosophila)
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASRGL1 asparaginase like 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BAMBI BMP and activin membrane-bound inhibitor
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CDC45 cell division cycle 45
CENPU centromere protein U
CKLF chemokine-like factor
CNN3 calponin 3, acidic
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CTSZ cathepsin Z
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
ITGB1BP1 integrin beta 1 binding protein 1
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100505650 uncharacterized LOC100505650
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
METRN meteorin, glial cell differentiation regulator
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MX1 MX dynamin-like GTPase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
PRSS3 protease, serine, 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RANBP1 RAN binding protein 1
RFC4 replication factor C (activator 1) 4, 37kDa
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TACC1 transforming, acidic coiled-coil containing protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TMEM223 transmembrane protein 223
TMX4 thioredoxin-related transmembrane protein 4
TRIB2 tribbles pseudokinase 2
TUBA4A tubulin, alpha 4a
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WSB2 WD repeat and SOCS box containing 2
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZWINT ZW10 interacting kinetochore protein