BRD-K65182930_NVP-AUY922_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

246 genes differentially expressed following the BRD-K65182930_NVP-AUY922_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNA1 cyclin A1
CCND2 cyclin D2
CCNG1 cyclin G1
CCNG2 cyclin G2
CD69 CD69 molecule
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRYAB crystallin, alpha B
CXCL10 chemokine (C-X-C motif) ligand 10
DDB2 damage-specific DNA binding protein 2, 48kDa
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DSE dermatan sulfate epimerase
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FDXR ferredoxin reductase
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GMPR guanosine monophosphate reductase
GPX3 glutathione peroxidase 3
GREB1 growth regulation by estrogen in breast cancer 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IL15 interleukin 15
KAZN kazrin, periplakin interacting protein
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KRT13 keratin 13, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LRPPRC leucine-rich pentatricopeptide repeat containing
MATN2 matrilin 2
NEFH neurofilament, heavy polypeptide
NOTCH1 notch 1
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
OSBPL9 oxysterol binding protein-like 9
P3H2 prolyl 3-hydroxylase 2
PEG3 paternally expressed 3
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RABGAP1L RAB GTPase activating protein 1-like
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPL28 ribosomal protein L28
RPS21 ribosomal protein S21
RPS27L ribosomal protein S27-like
SAT1 spermidine/spermine N1-acetyltransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SESN1 sestrin 1
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNX6 sorting nexin 6
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNC1 troponin C type 1 (slow)
TOX thymocyte selection-associated high mobility group box
TRIM22 tripartite motif containing 22
TTC3 tetratricopeptide repeat domain 3
TTC39A tetratricopeptide repeat domain 39A
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACOT7 acyl-CoA thioesterase 7
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ADAM19 ADAM metallopeptidase domain 19
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
ASPH aspartate beta-hydroxylase
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
BEX1 brain expressed, X-linked 1
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CCNE2 cyclin E2
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK2 cyclin-dependent kinase 2
CENPA centromere protein A
CEP170 centrosomal protein 170kDa
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
COL4A2 collagen, type IV, alpha 2
COL6A2 collagen, type VI, alpha 2
CST1 cystatin SN
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
DCBLD2 discoidin, CUB and LCCL domain containing 2
DGKZ diacylglycerol kinase, zeta
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMBP dynamin binding protein
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EFHD2 EF-hand domain family, member D2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EREG epiregulin
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD5 FXYD domain containing ion transport regulator 5
FZD7 frizzled class receptor 7
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
H2AFX H2A histone family, member X
HJURP Holliday junction recognition protein
HLA-DMA major histocompatibility complex, class II, DM alpha
HMGA2 high mobility group AT-hook 2
ICMT isoprenylcysteine carboxyl methyltransferase
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
LIF leukemia inhibitory factor
LINC00341 long intergenic non-protein coding RNA 341
LMNB2 lamin B2
MAP1B microtubule-associated protein 1B
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NES nestin
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRGN neurogranin (protein kinase C substrate, RC3)
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
OSBPL10 oxysterol binding protein-like 10
PARP2 poly (ADP-ribose) polymerase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEC plectin
PLK1 polo-like kinase 1
PMEPA1 prostate transmembrane protein, androgen induced 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RFC2 replication factor C (activator 1) 2, 40kDa
RIN2 Ras and Rab interactor 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPP25 ribonuclease P/MRP 25kDa subunit
RRM2 ribonucleotide reductase M2
SH2B3 SH2B adaptor protein 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAGP small cell adhesion glycoprotein
SOX9 SRY (sex determining region Y)-box 9
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX1A syntaxin 1A (brain)
SYNJ2 synaptojanin 2
TACC3 transforming, acidic coiled-coil containing protein 3
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLN1 talin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TNC tenascin C
TSPAN8 tetraspanin 8
WWTR1 WW domain containing transcription regulator 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta