BRD-K65182930_NVP-AUY922_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-K65182930_NVP-AUY922_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACSF2 acyl-CoA synthetase family member 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CCNG1 cyclin G1
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CGA glycoprotein hormones, alpha polypeptide
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNN1 calponin 1, basic, smooth muscle
CNOT2 CCR4-NOT transcription complex, subunit 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CRYAB crystallin, alpha B
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTIP cytohesin 1 interacting protein
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FDXR ferredoxin reductase
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAS6 growth arrest-specific 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GOLGA8B golgin A8 family, member B
GPC1 glypican 1
GUSBP3 glucuronidase, beta pseudogene 3
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KIZ kizuna centrosomal protein
KRT13 keratin 13, type I
LRPPRC leucine-rich pentatricopeptide repeat containing
MAOA monoamine oxidase A
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP5 microfibrillar associated protein 5
MYL9 myosin, light chain 9, regulatory
NEFH neurofilament, heavy polypeptide
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NXN nucleoredoxin
OSBPL9 oxysterol binding protein-like 9
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABGAP1L RAB GTPase activating protein 1-like
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RPS27L ribosomal protein S27-like
SESN1 sestrin 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNX6 sorting nexin 6
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TLE4 transducin-like enhancer of split 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSPYL5 TSPY-like 5
TTC39A tetratricopeptide repeat domain 39A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADAM19 ADAM metallopeptidase domain 19
AIM1 absent in melanoma 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARHGAP12 Rho GTPase activating protein 12
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
AURKB aurora kinase B
CCDC85B coiled-coil domain containing 85B
CCL21 chemokine (C-C motif) ligand 21
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COL6A1 collagen, type VI, alpha 1
CRIP2 cysteine-rich protein 2
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGA2 high mobility group AT-hook 2
HPCAL1 hippocalcin-like 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
JAG1 jagged 1
KIF14 kinesin family member 14
KRT81 keratin 81, type II
KYNU kynureninase
LAMB1 laminin, beta 1
LEF1 lymphoid enhancer-binding factor 1
LGALS2 lectin, galactoside-binding, soluble, 2
LIF leukemia inhibitory factor
MARCKSL1 MARCKS-like 1
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MIA melanoma inhibitory activity
MKI67 marker of proliferation Ki-67
MMD monocyte to macrophage differentiation-associated
MT1X metallothionein 1X
MT2A metallothionein 2A
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NES nestin
NET1 neuroepithelial cell transforming 1
NID1 nidogen 1
NRGN neurogranin (protein kinase C substrate, RC3)
NRN1 neuritin 1
NRP1 neuropilin 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
PMP22 peripheral myelin protein 22
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PRSS3 protease, serine, 3
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QPCT glutaminyl-peptide cyclotransferase
RRM2 ribonucleotide reductase M2
SCML1 sex comb on midleg-like 1 (Drosophila)
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH2B3 SH2B adaptor protein 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMAGP small cell adhesion glycoprotein
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB2 tribbles pseudokinase 2
TSPAN4 tetraspanin 4
TUBB2A tubulin, beta 2A class IIa
UBE2S ubiquitin-conjugating enzyme E2S
WWTR1 WW domain containing transcription regulator 1