BRD-K64890080_BI-2536_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K64890080_BI-2536_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AQP1 aquaporin 1 (Colton blood group)
BTG2 BTG family, member 2
CD34 CD34 molecule
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CKB creatine kinase, brain
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GHR growth hormone receptor
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
JUNB jun B proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
LGMN legumain
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC2 syndecan 2
SFTPB surfactant protein B
SYNE2 spectrin repeat containing, nuclear envelope 2
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TSPAN7 tetraspanin 7
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
BMP4 bone morphogenetic protein 4
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CRISP3 cysteine-rich secretory protein 3
CTSG cathepsin G
CXCL14 chemokine (C-X-C motif) ligand 14
DACH1 dachshund family transcription factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGFR epidermal growth factor receptor
ELANE elastase, neutrophil expressed
EMP3 epithelial membrane protein 3
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
EVI2B ecotropic viral integration site 2B
F2RL1 coagulation factor II (thrombin) receptor-like 1
GATA3 GATA binding protein 3
GTPBP8 GTP-binding protein 8 (putative)
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LTF lactotransferrin
MBP myelin basic protein
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG1 neuregulin 1
OLFM4 olfactomedin 4
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PTX3 pentraxin 3, long
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRI sorcin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TPSAB1 tryptase alpha/beta 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)