BRD-K64890080_BI-2536_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K64890080_BI-2536_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADI1 acireductone dioxygenase 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCDC85B coiled-coil domain containing 85B
CCNG2 cyclin G2
CFD complement factor D (adipsin)
CHMP4A charged multivesicular body protein 4A
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CTTN cortactin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FBXO2 F-box protein 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAS6 growth arrest-specific 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HMG20B high mobility group 20B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
INSIG1 insulin induced gene 1
KIF2C kinesin family member 2C
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LGMN legumain
LIMCH1 LIM and calponin homology domains 1
LRRC16A leucine rich repeat containing 16A
LTBP3 latent transforming growth factor beta binding protein 3
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MXD4 MAX dimerization protein 4
NDNF neuron-derived neurotrophic factor
NEU1 sialidase 1 (lysosomal sialidase)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
OSR2 odd-skipped related transciption factor 2
PDGFRL platelet-derived growth factor receptor-like
PNRC1 proline-rich nuclear receptor coactivator 1
POR P450 (cytochrome) oxidoreductase
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SFRP4 secreted frizzled-related protein 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQLE squalene epoxidase
SSR4 signal sequence receptor, delta
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TPD52L1 tumor protein D52-like 1
TUBA1A tubulin, alpha 1a
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CCNE2 cyclin E2
CD200 CD200 molecule
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CHPT1 choline phosphotransferase 1
CKAP4 cytoskeleton-associated protein 4
CNN3 calponin 3, acidic
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFS embryonal Fyn-associated substrate
EHF ets homologous factor
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
FXYD3 FXYD domain containing ion transport regulator 3
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
HOXB7 homeobox B7
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LMNB1 lamin B1
LMO4 LIM domain only 4
LY6D lymphocyte antigen 6 complex, locus D
MAPK13 mitogen-activated protein kinase 13
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MSMB microseminoprotein, beta-
MSRA methionine sulfoxide reductase A
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDRG2 NDRG family member 2
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PDHX pyruvate dehydrogenase complex, component X
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PNMA2 paraneoplastic Ma antigen 2
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCH protein kinase C, eta
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RRM1 ribonucleotide reductase M1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SELL selectin L
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A1 solute carrier family 38, member 1
SORBS3 sorbin and SH3 domain containing 3
SPDL1 spindle apparatus coiled-coil protein 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TMPO thymopoietin
TRBC1 T cell receptor beta constant 1
USP1 ubiquitin specific peptidase 1
ZNF22 zinc finger protein 22
ZWINT ZW10 interacting kinetochore protein