BRD-K64890080_BI-2536_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-K64890080_BI-2536_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AACS acetoacetyl-CoA synthetase
ABAT 4-aminobutyrate aminotransferase
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
ASCL1 achaete-scute family bHLH transcription factor 1
ASMTL acetylserotonin O-methyltransferase-like
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
C9ORF16 chromosome 9 open reading frame 16
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CALCA calcitonin-related polypeptide alpha
CCDC85B coiled-coil domain containing 85B
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CHGB chromogranin B
CIRBP cold inducible RNA binding protein
CLDN3 claudin 3
CLU clusterin
COMP cartilage oligomeric matrix protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXADR coxsackie virus and adenovirus receptor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP4 dual specificity phosphatase 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
EZR ezrin
FADS1 fatty acid desaturase 1
FAM46A family with sequence similarity 46, member A
FBXO2 F-box protein 2
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GDE1 glycerophosphodiester phosphodiesterase 1
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GRN granulin
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
IDUA iduronidase, alpha-L-
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISG15 ISG15 ubiquitin-like modifier
JAK1 Janus kinase 1
JUND jun D proto-oncogene
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIF2C kinesin family member 2C
LAGE3 L antigen family, member 3
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
LGMN legumain
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRN3 leucine rich repeat neuronal 3
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MATN2 matrilin 2
METRN meteorin, glial cell differentiation regulator
MKNK2 MAP kinase interacting serine/threonine kinase 2
MT1X metallothionein 1X
NDNF neuron-derived neurotrophic factor
NDRG4 NDRG family member 4
NEBL nebulette
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCYOX1 prenylcysteine oxidase 1
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PON3 paraoxonase 3
POR P450 (cytochrome) oxidoreductase
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRAF2 PRA1 domain family, member 2
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
REEP1 receptor accessory protein 1
RNASET2 ribonuclease T2
RTN3 reticulon 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TGFBR3 transforming growth factor, beta receptor III
THEMIS2 thymocyte selection associated family member 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TPD52L1 tumor protein D52-like 1
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ATF1 activating transcription factor 1
BCL2A1 BCL2-related protein A1
BLMH bleomycin hydrolase
CA12 carbonic anhydrase XII
CD69 CD69 molecule
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC2B C-type lectin domain family 2, member B
COL4A2 collagen, type IV, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DEK DEK proto-oncogene
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FBL fibrillarin
FBN2 fibrillin 2
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
HMGA2 high mobility group AT-hook 2
HOXB7 homeobox B7
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IL1B interleukin 1, beta
IPO5 importin 5
JADE2 jade family PHD finger 2
KRT18 keratin 18, type I
LMNB1 lamin B1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK13 mitogen-activated protein kinase 13
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
P3H2 prolyl 3-hydroxylase 2
PARP2 poly (ADP-ribose) polymerase 2
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PLSCR1 phospholipid scramblase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PYCR1 pyrroline-5-carboxylate reductase 1
RFC4 replication factor C (activator 1) 4, 37kDa
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATS2L spermatogenesis associated, serine-rich 2-like
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TMEM97 transmembrane protein 97
TSPAN4 tetraspanin 4
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
USP1 ubiquitin specific peptidase 1
YBX3 Y box binding protein 3
ZEB1 zinc finger E-box binding homeobox 1