BRD-K64890080_BI-2536_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

205 genes differentially expressed following the BRD-K64890080_BI-2536_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ANXA3 annexin A3
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CDC20 cell division cycle 20
CDH17 cadherin 17, LI cadherin (liver-intestine)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSB cathepsin B
CYBB cytochrome b-245, beta polypeptide
DAPK1 death-associated protein kinase 1
DMXL2 Dmx-like 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHB2 EPH receptor B2
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
FAM50A family with sequence similarity 50, member A
FBXO2 F-box protein 2
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGB fibrinogen beta chain
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
GALC galactosylceramidase
GATA6 GATA binding protein 6
GLUL glutamate-ammonia ligase
GMPR guanosine monophosphate reductase
GPR137B G protein-coupled receptor 137B
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
HEPH hephaestin
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IL1R2 interleukin 1 receptor, type II
ISG15 ISG15 ubiquitin-like modifier
JAK1 Janus kinase 1
JUN jun proto-oncogene
KIAA1033 KIAA1033
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LDOC1 leucine zipper, down-regulated in cancer 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MSRB2 methionine sulfoxide reductase B2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NPC2 Niemann-Pick disease, type C2
NRCAM neuronal cell adhesion molecule
NRG1 neuregulin 1
OLFM4 olfactomedin 4
PDLIM5 PDZ and LIM domain 5
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLS1 plastin 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PNOC prepronociceptin
PRAF2 PRA1 domain family, member 2
RAB31 RAB31, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGC Ras-related GTP binding C
S100A12 S100 calcium binding protein A12
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCG5 secretogranin V
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SNAP25 synaptosomal-associated protein, 25kDa
STXBP1 syntaxin binding protein 1
TACC1 transforming, acidic coiled-coil containing protein 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
AKAP1 A kinase (PRKA) anchor protein 1
ANK2 ankyrin 2, neuronal
ANO1 anoctamin 1, calcium activated chloride channel
AQP3 aquaporin 3 (Gill blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
C1QBP complement component 1, q subcomponent binding protein
CANT1 calcium activated nucleotidase 1
CCL19 chemokine (C-C motif) ligand 19
CD2 CD2 molecule
CD200 CD200 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKAP4 cytoskeleton-associated protein 4
COL14A1 collagen, type XIV, alpha 1
COL15A1 collagen, type XV, alpha 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DCTD dCMP deaminase
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEPTOR DEP domain containing MTOR-interacting protein
DPP4 dipeptidyl-peptidase 4
EFS embryonal Fyn-associated substrate
ESR1 estrogen receptor 1
ETV1 ets variant 1
F12 coagulation factor XII (Hageman factor)
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FRZB frizzled-related protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPM6B glycoprotein M6B
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMK granzyme K (granzyme 3; tryptase II)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA1 high mobility group AT-hook 1
HOXC6 homeobox C6
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITM2A integral membrane protein 2A
KAZN kazrin, periplakin interacting protein
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LINC00341 long intergenic non-protein coding RNA 341
LPL lipoprotein lipase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MAMLD1 mastermind-like domain containing 1
MCM3 minichromosome maintenance complex component 3
MGP matrix Gla protein
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NKG7 natural killer cell granule protein 7
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PCOLCE procollagen C-endopeptidase enhancer
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PERP PERP, TP53 apoptosis effector
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRKCH protein kinase C, eta
PROM1 prominin 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAD23B RAD23 homolog B (S. cerevisiae)
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF167 ring finger protein 167
RPL39L ribosomal protein L39-like
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORBS2 sorbin and SH3 domain containing 2
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
STEAP3 STEAP family member 3, metalloreductase
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNC tenascin C
TSC22D3 TSC22 domain family, member 3
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
ZDHHC6 zinc finger, DHHC-type containing 6