BRD-K64890080_BI-2536_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-K64890080_BI-2536_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
BPHL biphenyl hydrolase-like (serine hydrolase)
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CCNB2 cyclin B2
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLSTN1 calsyntenin 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DST dystonin
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAS2L1 growth arrest-specific 2 like 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
HMG20B high mobility group 20B
HOOK2 hook microtubule-tethering protein 2
IER5 immediate early response 5
KDM4B lysine (K)-specific demethylase 4B
KIF14 kinesin family member 14
KTN1 kinectin 1 (kinesin receptor)
LDLR low density lipoprotein receptor
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDLIM5 PDZ and LIM domain 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRSS2 protease, serine, 2 (trypsin 2)
RBBP6 retinoblastoma binding protein 6
RRAGC Ras-related GTP binding C
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RUNX3 runt-related transcription factor 3
SEC62 SEC62 homolog (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SH2B3 SH2B adaptor protein 3
STAR steroidogenic acute regulatory protein
STXBP1 syntaxin binding protein 1
TFF1 trefoil factor 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNIK TRAF2 and NCK interacting kinase
ZCCHC14 zinc finger, CCHC domain containing 14

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRE5 adhesion G protein-coupled receptor E5
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APP amyloid beta (A4) precursor protein
ARG1 arginase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPN asporin
B3GNT1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CCNE2 cyclin E2
CD200 CD200 molecule
CD24 CD24 molecule
CD34 CD34 molecule
CD58 CD58 molecule
CDCA4 cell division cycle associated 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKAP4 cytoskeleton-associated protein 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMX2 empty spiracles homeobox 2
EYA2 EYA transcriptional coactivator and phosphatase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FMOD fibromodulin
G0S2 G0/G1 switch 2
GAS7 growth arrest-specific 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCA grancalcin, EF-hand calcium binding protein
GLUL glutamate-ammonia ligase
GOLT1B golgi transport 1B
GPC3 glypican 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HOXA5 homeobox A5
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IL2RG interleukin 2 receptor, gamma
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG2 insulin induced gene 2
IRF1 interferon regulatory factor 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT13 keratin 13, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LMNB1 lamin B1
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
MAOA monoamine oxidase A
MBP myelin basic protein
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MFAP2 microfibrillar-associated protein 2
MPZL2 myelin protein zero-like 2
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXRA5 matrix-remodelling associated 5
NREP neuronal regeneration related protein
PCP4 Purkinje cell protein 4
PDGFRL platelet-derived growth factor receptor-like
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLBD1 phospholipase B domain containing 1
PLTP phospholipid transfer protein
POU2AF1 POU class 2 associating factor 1
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PSPH phosphoserine phosphatase
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PVALB parvalbumin
RAB25 RAB25, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RNASE4 ribonuclease, RNase A family, 4
S100P S100 calcium binding protein P
SLIT2 slit homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
STK39 serine threonine kinase 39
SULF1 sulfatase 1
TAGLN transgelin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TRIB1 tribbles pseudokinase 1
TSPAN6 tetraspanin 6
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAM1 vascular cell adhesion molecule 1
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2