BRD-K64890080_BI-2536_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-K64890080_BI-2536_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ADM adrenomedullin
AKIRIN1 akirin 1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CAPN3 calpain 3, (p94)
CCDC85B coiled-coil domain containing 85B
CDC20 cell division cycle 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DUSP4 dual specificity phosphatase 4
EDNRB endothelin receptor type B
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPHA3 EPH receptor A3
EPHB2 EPH receptor B2
EZR ezrin
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FOLR1 folate receptor 1 (adult)
GABARAPL1 GABA(A) receptor-associated protein like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GMPR guanosine monophosphate reductase
GPATCH8 G patch domain containing 8
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HN1 hematological and neurological expressed 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGKC immunoglobulin kappa constant
ITGA6 integrin, alpha 6
JAK1 Janus kinase 1
KDM3A lysine (K)-specific demethylase 3A
KDM4B lysine (K)-specific demethylase 4B
KIF2C kinesin family member 2C
KLF5 Kruppel-like factor 5 (intestinal)
KTN1 kinectin 1 (kinesin receptor)
LAMP3 lysosomal-associated membrane protein 3
LAMP5 lysosomal-associated membrane protein family, member 5
LCN2 lipocalin 2
LGMN legumain
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MACF1 microtubule-actin crosslinking factor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
MATN2 matrilin 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYO6 myosin VI
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NDRG4 NDRG family member 4
NEBL nebulette
NMT2 N-myristoyltransferase 2
NOSIP nitric oxide synthase interacting protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG1 neuregulin 1
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PCCB propionyl CoA carboxylase, beta polypeptide
PCDH9 protocadherin 9
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PKN2 protein kinase N2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
POU4F1 POU class 4 homeobox 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPCT glutaminyl-peptide cyclotransferase
RBP1 retinol binding protein 1, cellular
RCOR1 REST corepressor 1
RLF rearranged L-myc fusion
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SON SON DNA binding protein
SOX9 SRY (sex determining region Y)-box 9
STAR steroidogenic acute regulatory protein
STXBP1 syntaxin binding protein 1
TBX3 T-box 3
TCL1A T-cell leukemia/lymphoma 1A
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM47 transmembrane protein 47
TOB1 transducer of ERBB2, 1
TSPAN3 tetraspanin 3
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP9X ubiquitin specific peptidase 9, X-linked
VAT1 vesicle amine transport 1
VLDLR very low density lipoprotein receptor
VNN1 vanin 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF1 activating transcription factor 1
ATXN10 ataxin 10
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
CA12 carbonic anhydrase XII
CALR calreticulin
CCNE2 cyclin E2
CD163 CD163 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A2 collagen, type VI, alpha 2
CP ceruloplasmin (ferroxidase)
DCK deoxycytidine kinase
DCLK1 doublecortin-like kinase 1
ELOVL6 ELOVL fatty acid elongase 6
EML3 echinoderm microtubule associated protein like 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM129A family with sequence similarity 129, member A
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GRB10 growth factor receptor-bound protein 10
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPB1 heat shock 27kDa protein 1
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
INHBA inhibin, beta A
JADE2 jade family PHD finger 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF20A kinesin family member 20A
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MDK midkine (neurite growth-promoting factor 2)
MFAP2 microfibrillar-associated protein 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
NGRN neugrin, neurite outgrowth associated
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NNT nicotinamide nucleotide transhydrogenase
NREP neuronal regeneration related protein
NUCB2 nucleobindin 2
PARP2 poly (ADP-ribose) polymerase 2
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POSTN periostin, osteoblast specific factor
PRKCA protein kinase C, alpha
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
PYCR1 pyrroline-5-carboxylate reductase 1
RAB13 RAB13, member RAS oncogene family
RAI14 retinoic acid induced 14
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFTN1 raftlin, lipid raft linker 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPS11 ribosomal protein S11
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SECTM1 secreted and transmembrane 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLA Src-like-adaptor
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC43A3 solute carrier family 43, member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORBS3 sorbin and SH3 domain containing 3
SOX11 SRY (sex determining region Y)-box 11
SPARCL1 SPARC-like 1 (hevin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULF1 sulfatase 1
TARP TCR gamma alternate reading frame protein
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TRIM14 tripartite motif containing 14
TSC22D1 TSC22 domain family, member 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAMP8 vesicle-associated membrane protein 8
ZNF232 zinc finger protein 232