BRD-K64890080_BI-2536_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K64890080_BI-2536_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP13 A kinase (PRKA) anchor protein 13
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD9 CD9 molecule
CDC25B cell division cycle 25B
CES1 carboxylesterase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDHD2 DDHD domain containing 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHDDS dehydrodolichyl diphosphate synthase
DPYSL2 dihydropyrimidinase-like 2
EFNB2 ephrin-B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FNBP1 formin binding protein 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
GALC galactosylceramidase
GLG1 golgi glycoprotein 1
GNAS GNAS complex locus
GOLGA8H golgin A8 family, member H
GSN gelsolin
H2AFV H2A histone family, member V
H2BFS H2B histone family, member S (pseudogene)
HDAC6 histone deacetylase 6
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT74 intraflagellar transport 74
INSR insulin receptor
KLHDC10 kelch domain containing 10
LBH limb bud and heart development
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MXD4 MAX dimerization protein 4
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PNMA1 paraneoplastic Ma antigen 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABGAP1 RAB GTPase activating protein 1
RGS10 regulator of G-protein signaling 10
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN3 reticulon 3
RYBP RING1 and YY1 binding protein
SCPEP1 serine carboxypeptidase 1
SECISBP2L SECIS binding protein 2-like
SESN1 sestrin 1
SIDT2 SID1 transmembrane family, member 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSPYL5 TSPY-like 5
UBE2S ubiquitin-conjugating enzyme E2S
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABLIM1 actin binding LIM protein 1
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOA2 apolipoprotein A-II
ARG1 arginase 1
ARL4C ADP-ribosylation factor-like 4C
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CD200 CD200 molecule
CD24 CD24 molecule
CDK4 cyclin-dependent kinase 4
CFB complement factor B
CFI complement factor I
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A1 collagen, type V, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ERAP1 endoplasmic reticulum aminopeptidase 1
F12 coagulation factor XII (Hageman factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
F5 coagulation factor V (proaccelerin, labile factor)
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GBP1 guanylate binding protein 1, interferon-inducible
GUSBP3 glucuronidase, beta pseudogene 3
HACD3 3-hydroxyacyl-CoA dehydratase 3
HOXB7 homeobox B7
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0101 KIAA0101
KRT23 keratin 23, type I
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MMP11 matrix metallopeptidase 11
MMP9 matrix metallopeptidase 9
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NNMT nicotinamide N-methyltransferase
NOP16 NOP16 nucleolar protein
NXT1 nuclear transport factor 2-like export factor 1
OSMR oncostatin M receptor
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PCOLCE procollagen C-endopeptidase enhancer
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PXDN peroxidasin
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
RPL10 ribosomal protein L10
SCEL sciellin
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SRM spermidine synthase
SRPK1 SRSF protein kinase 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TTR transthyretin
TYMS thymidylate synthetase
UGDH UDP-glucose 6-dehydrogenase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP6NL USP6 N-terminal like
VCAM1 vascular cell adhesion molecule 1
VCAN versican
WBP5 WW domain binding protein 5
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1