BRD-K64890080_BI-2536_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K64890080_BI-2536_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AURKA aurora kinase A
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CD44 CD44 molecule (Indian blood group)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CIT citron rho-interacting serine/threonine kinase
CKAP2 cytoskeleton associated protein 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FGFR3 fibroblast growth factor receptor 3
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2BG histone cluster 1, H2bg
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIF20A kinesin family member 20A
LMO3 LIM domain only 3 (rhombotin-like 2)
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
NPY1R neuropeptide Y receptor Y1
PAWR PRKC, apoptosis, WT1, regulator
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSRC1 proline/serine-rich coiled-coil 1
RHOBTB3 Rho-related BTB domain containing 3
TPX2 TPX2, microtubule-associated
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BCL2A1 BCL2-related protein A1
C10ORF10 chromosome 10 open reading frame 10
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD200 CD200 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CSTA cystatin A (stefin A)
CTSK cathepsin K
EGFL6 EGF-like-domain, multiple 6
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FCGBP Fc fragment of IgG binding protein
FKBP11 FK506 binding protein 11, 19 kDa
FMOD fibromodulin
FRZB frizzled-related protein
GSTP1 glutathione S-transferase pi 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP3 insulin-like growth factor binding protein 3
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MPZL2 myelin protein zero-like 2
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOV nephroblastoma overexpressed
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PYCR1 pyrroline-5-carboxylate reductase 1
S100A7 S100 calcium binding protein A7
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORBS2 sorbin and SH3 domain containing 2
SYBU syntabulin (syntaxin-interacting)
TARP TCR gamma alternate reading frame protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)