BRD-K64890080_BI-2536_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K64890080_BI-2536_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCDC85B coiled-coil domain containing 85B
COL11A1 collagen, type XI, alpha 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EGR1 early growth response 1
EIF3B eukaryotic translation initiation factor 3, subunit B
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GEM GTP binding protein overexpressed in skeletal muscle
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IGKC immunoglobulin kappa constant
LIMA1 LIM domain and actin binding 1
LRRC15 leucine rich repeat containing 15
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDNF neuron-derived neurotrophic factor
NXN nucleoredoxin
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SNX11 sorting nexin 11
TIMP3 TIMP metallopeptidase inhibitor 3
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABLIM1 actin binding LIM protein 1
ADGRG1 adhesion G protein-coupled receptor G1
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AHSG alpha-2-HS-glycoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOH apolipoprotein H (beta-2-glycoprotein I)
ASPH aspartate beta-hydroxylase
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
C1S complement component 1, s subcomponent
C5 complement component 5
CCDC109B coiled-coil domain containing 109B
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK1 cyclin-dependent kinase 1
CLU clusterin
COL1A2 collagen, type I, alpha 2
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CTSB cathepsin B
CXCL5 chemokine (C-X-C motif) ligand 5
DEFB1 defensin, beta 1
EDN1 endothelin 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FXYD2 FXYD domain containing ion transport regulator 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GSAP gamma-secretase activating protein
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT18 keratin 18, type I
KRT4 keratin 4, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LYZ lysozyme
MATN2 matrilin 2
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
MTMR11 myotubularin related protein 11
MYO5C myosin VC
NOTCH3 notch 3
NPR3 natriuretic peptide receptor 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUPR1 nuclear protein, transcriptional regulator, 1
PAIP1 poly(A) binding protein interacting protein 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEG10 paternally expressed 10
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSPH phosphoserine phosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RHOBTB1 Rho-related BTB domain containing 1
RNASE4 ribonuclease, RNase A family, 4
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGCE sarcoglycan, epsilon
SLC16A4 solute carrier family 16, member 4
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TMEM100 transmembrane protein 100
TRIM16 tripartite motif containing 16
TSPAN6 tetraspanin 6
TXN thioredoxin
UBE2C ubiquitin-conjugating enzyme E2C
UPK1B uroplakin 1B
VCAM1 vascular cell adhesion molecule 1
VCAN versican