BRD-K64890080_BI-2536_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K64890080_BI-2536_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AACS acetoacetyl-CoA synthetase
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA3 annexin A3
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CAV2 caveolin 2
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CLGN calmegin
CLU clusterin
CTH cystathionine gamma-lyase
DHCR7 7-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
EZR ezrin
G6PD glucose-6-phosphate dehydrogenase
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GLCE glucuronic acid epimerase
GREB1 growth regulation by estrogen in breast cancer 1
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HGD homogentisate 1,2-dioxygenase
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
INSIG1 insulin induced gene 1
JAK1 Janus kinase 1
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LGMN legumain
MACF1 microtubule-actin crosslinking factor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEST mesoderm specific transcript
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MYO1B myosin IB
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NEB nebulin
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
OPN3 opsin 3
OSR2 odd-skipped related transciption factor 2
PALMD palmdelphin
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLK2 polo-like kinase 2
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAP prosaposin
RBP1 retinol binding protein 1, cellular
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIK1 salt-inducible kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOX9 SRY (sex determining region Y)-box 9
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
STK38 serine/threonine kinase 38
STXBP1 syntaxin binding protein 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
VLDLR very low density lipoprotein receptor
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX6 armadillo repeat containing, X-linked 6
ATF1 activating transcription factor 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC20 cell division cycle 20
CDC45 cell division cycle 45
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM60A family with sequence similarity 60, member A
FST follistatin
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPX1 glutathione peroxidase 1
GYPC glycophorin C (Gerbich blood group)
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXB7 homeobox B7
ICAM3 intercellular adhesion molecule 3
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
INHBA inhibin, beta A
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KRT18 keratin 18, type I
LMNB1 lamin B1
MAP7 microtubule-associated protein 7
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MOK MOK protein kinase
MRPL15 mitochondrial ribosomal protein L15
NNMT nicotinamide N-methyltransferase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PYCR1 pyrroline-5-carboxylate reductase 1
RAB13 RAB13, member RAS oncogene family
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFTN1 raftlin, lipid raft linker 1
S100A2 S100 calcium binding protein A2
SEPHS1 selenophosphate synthetase 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SNX10 sorting nexin 10
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRI sorcin
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPIN TIMELESS interacting protein
TLR4 toll-like receptor 4
TMEM97 transmembrane protein 97
TRIP13 thyroid hormone receptor interactor 13
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
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