BRD-K64890080_BI-2536_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K64890080_BI-2536_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AGTPBP1 ATP/GTP binding protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASS1 argininosuccinate synthase 1
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
BZW1 basic leucine zipper and W2 domains 1
CD38 CD38 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL14A1 collagen, type XIV, alpha 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM117A family with sequence similarity 117, member A
FGFR1 fibroblast growth factor receptor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GOLGA8H golgin A8 family, member H
GPI glucose-6-phosphate isomerase
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HSPA4L heat shock 70kDa protein 4-like
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
JAK1 Janus kinase 1
LGMN legumain
MAST2 microtubule associated serine/threonine kinase 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
NEB nebulin
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
OSBPL3 oxysterol binding protein-like 3
PEG10 paternally expressed 10
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPL periplakin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTTG1IP pituitary tumor-transforming 1 interacting protein
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
SEPT10 septin 10
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STXBP1 syntaxin binding protein 1
TGFBR3 transforming growth factor, beta receptor III
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSPAN7 tetraspanin 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VLDLR very low density lipoprotein receptor
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
CCND2 cyclin D2
CCNE2 cyclin E2
CD200 CD200 molecule
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CDK1 cyclin-dependent kinase 1
COBL cordon-bleu WH2 repeat protein
CTBP2 C-terminal binding protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
EFS embryonal Fyn-associated substrate
EHF ets homologous factor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOSC8 exosome component 8
FMO3 flavin containing monooxygenase 3
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GUCY1B3 guanylate cyclase 1, soluble, beta 3
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGF1R insulin-like growth factor 1 receptor
IL17RB interleukin 17 receptor B
IRS2 insulin receptor substrate 2
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KIAA0125 KIAA0125
KIF20A kinesin family member 20A
LMNB1 lamin B1
LXN latexin
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NES nestin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NSG1 neuron specific gene family member 1
NUPR1 nuclear protein, transcriptional regulator, 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRR15L proline rich 15-like
PYCR1 pyrroline-5-carboxylate reductase 1
RAB13 RAB13, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFC3 replication factor C (activator 1) 3, 38kDa
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC38A1 solute carrier family 38, member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD1 SMAD family member 1
SORBS2 sorbin and SH3 domain containing 2
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF7 serine/arginine-rich splicing factor 7
SST somatostatin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D1 TSC22 domain family, member 1
UFM1 ubiquitin-fold modifier 1
WFDC1 WAP four-disulfide core domain 1
WNT5A wingless-type MMTV integration site family, member 5A
ZNF91 zinc finger protein 91