BRD-K64890080_BI 2536_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K64890080_BI 2536_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTC1 actin, alpha, cardiac muscle 1
ALDOC aldolase C, fructose-bisphosphate
ANXA4 annexin A4
ASMTL acetylserotonin O-methyltransferase-like
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DHCR7 7-dehydrocholesterol reductase
DNM1L dynamin 1-like
EFNB2 ephrin-B2
FABP4 fatty acid binding protein 4, adipocyte
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FN1 fibronectin 1
FNBP1 formin binding protein 1
FOXN3 forkhead box N3
FZD1 frizzled class receptor 1
G6PD glucose-6-phosphate dehydrogenase
GATA6 GATA binding protein 6
GM2A GM2 ganglioside activator
GSTA4 glutathione S-transferase alpha 4
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGHA1 immunoglobulin heavy constant alpha 1
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
KDM3A lysine (K)-specific demethylase 3A
KIAA1033 KIAA1033
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LGMN legumain
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGEB2 melanoma antigen family B2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCOLN1 mucolipin 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSMO1 methylsterol monooxygenase 1
NCOA3 nuclear receptor coactivator 3
NDN necdin, melanoma antigen (MAGE) family member
NEU1 sialidase 1 (lysosomal sialidase)
OPN3 opsin 3
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZD2 PDZ domain containing 2
PLK2 polo-like kinase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS13 regulator of G-protein signaling 13
RNF103 ring finger protein 103
RRBP1 ribosome binding protein 1
RSRP1 arginine/serine-rich protein 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SMC4 structural maintenance of chromosomes 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STXBP1 syntaxin binding protein 1
TACC1 transforming, acidic coiled-coil containing protein 1
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TLE4 transducin-like enhancer of split 4
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
UBE2A ubiquitin-conjugating enzyme E2A
ZFAND5 zinc finger, AN1-type domain 5
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ATF1 activating transcription factor 1
B3GNT1
CD320 CD320 molecule
CDC42 cell division cycle 42
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DCTD dCMP deaminase
DCTPP1 dCTP pyrophosphatase 1
EMP1 epithelial membrane protein 1
EREG epiregulin
FHOD3 formin homology 2 domain containing 3
FOSL1 FOS-like antigen 1
GPR171 G protein-coupled receptor 171
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTO1 glutathione S-transferase omega 1
HBB hemoglobin, beta
HOXB7 homeobox B7
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IL27RA interleukin 27 receptor, alpha
MAPK13 mitogen-activated protein kinase 13
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
METTL9 methyltransferase like 9
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL19 mitochondrial ribosomal protein L19
MRPL3 mitochondrial ribosomal protein L3
MRPS2 mitochondrial ribosomal protein S2
NME4 NME/NM23 nucleoside diphosphate kinase 4
OLFM4 olfactomedin 4
PARL presenilin associated, rhomboid-like
PKP4 plakophilin 4
PLAC8 placenta-specific 8
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGCC regulator of cell cycle
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SMAGP small cell adhesion glycoprotein
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TFPI2 tissue factor pathway inhibitor 2
VCAN versican