BRD-K64890080_BI 2536_SKLU1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-K64890080_BI 2536_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASS1 argininosuccinate synthase 1
ATP11B ATPase, class VI, type 11B
AZIN1 antizyme inhibitor 1
BAMBI BMP and activin membrane-bound inhibitor
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA1 chloride channel accessory 1
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
CTH cystathionine gamma-lyase
DEFA4 defensin, alpha 4, corticostatin
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FGFR3 fibroblast growth factor receptor 3
GAL galanin/GMAP prepropeptide
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HLA-DOB major histocompatibility complex, class II, DO beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
KRT23 keratin 23, type I
MAN1A1 mannosidase, alpha, class 1A, member 1
MSMO1 methylsterol monooxygenase 1
MZB1 marginal zone B and B1 cell-specific protein
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NOTCH1 notch 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OPN3 opsin 3
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
POU2AF1 POU class 2 associating factor 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRTN3 proteinase 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAB4A RAB4A, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RGCC regulator of cell cycle
RRAD Ras-related associated with diabetes
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIK1 salt-inducible kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SQLE squalene epoxidase
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STAT1 signal transducer and activator of transcription 1, 91kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBD thrombomodulin
TLE4 transducin-like enhancer of split 4
TMEM2 transmembrane protein 2
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WDR47 WD repeat domain 47
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AAK1 AP2 associated kinase 1
ALCAM activated leukocyte cell adhesion molecule
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA10 annexin A10
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
B3GNT1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BHLHE41 basic helix-loop-helix family, member e41
CBR3 carbonyl reductase 3
CCDC86 coiled-coil domain containing 86
CHIC2 cysteine-rich hydrophobic domain 2
CHMP6 charged multivesicular body protein 6
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CTSB cathepsin B
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
ECI2 enoyl-CoA delta isomerase 2
EIF4B eukaryotic translation initiation factor 4B
EMG1 EMG1 N1-specific pseudouridine methyltransferase
F3 coagulation factor III (thromboplastin, tissue factor)
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLOD4 glyoxalase domain containing 4
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0753 KIAA0753
LAMB3 laminin, beta 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPAR1 lysophosphatidic acid receptor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MT1M metallothionein 1M
MXRA7 matrix-remodelling associated 7
MYH11 myosin, heavy chain 11, smooth muscle
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NMI N-myc (and STAT) interactor
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP2 poly (ADP-ribose) polymerase 2
PAX8 paired box 8
PDZRN3 PDZ domain containing ring finger 3
PFKP phosphofructokinase, platelet
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLBD1 phospholipase B domain containing 1
PMP22 peripheral myelin protein 22
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS2 protease, serine, 2 (trypsin 2)
PSD3 pleckstrin and Sec7 domain containing 3
RNASE4 ribonuclease, RNase A family, 4
RPL39L ribosomal protein L39-like
RSAD1 radical S-adenosyl methionine domain containing 1
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORBS3 sorbin and SH3 domain containing 3
SPRY2 sprouty homolog 2 (Drosophila)
STAMBP STAM binding protein
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TLE2 transducin-like enhancer of split 2
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNIP1 TNFAIP3 interacting protein 1
TPCN1 two pore segment channel 1
TRIP13 thyroid hormone receptor interactor 13
WNT5A wingless-type MMTV integration site family, member 5A
ZNF22 zinc finger protein 22