BRD-K64857848_XMD-885_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K64857848_XMD-885_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AK1 adenylate kinase 1
ASXL2 additional sex combs like transcriptional regulator 2
ATP10D ATPase, class V, type 10D
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCNA1 cyclin A1
CD24 CD24 molecule
COMP cartilage oligomeric matrix protein
CPB1 carboxypeptidase B1 (tissue)
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CYBA cytochrome b-245, alpha polypeptide
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPHA3 EPH receptor A3
FABP7 fatty acid binding protein 7, brain
FAM3C family with sequence similarity 3, member C
FXYD2 FXYD domain containing ion transport regulator 2
GAS1 growth arrest-specific 1
GNB5 guanine nucleotide binding protein (G protein), beta 5
GRB14 growth factor receptor-bound protein 14
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST2H2BE histone cluster 2, H2be
HOXA5 homeobox A5
IFITM2 interferon induced transmembrane protein 2
IGHM immunoglobulin heavy constant mu
ISG20 interferon stimulated exonuclease gene 20kDa
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
NCAM1 neural cell adhesion molecule 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRIP3 nuclear receptor interacting protein 3
PCTP phosphatidylcholine transfer protein
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIRT3 sirtuin 3
SLPI secretory leukocyte peptidase inhibitor
SNRPE small nuclear ribonucleoprotein polypeptide E
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM47 transmembrane protein 47
TXN thioredoxin
TXNIP thioredoxin interacting protein
WFDC2 WAP four-disulfide core domain 2
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
BPHL biphenyl hydrolase-like (serine hydrolase)
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C14ORF132 chromosome 14 open reading frame 132
CCDC86 coiled-coil domain containing 86
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHIC2 cysteine-rich hydrophobic domain 2
CHL1 cell adhesion molecule L1-like
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKAP4 cytoskeleton-associated protein 4
CLPTM1 cleft lip and palate associated transmembrane protein 1
CPE carboxypeptidase E
CREG1 cellular repressor of E1A-stimulated genes 1
CSAD cysteine sulfinic acid decarboxylase
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EIF5 eukaryotic translation initiation factor 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBXL12 F-box and leucine-rich repeat protein 12
FXYD3 FXYD domain containing ion transport regulator 3
GJA1 gap junction protein, alpha 1, 43kDa
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
IL1R1 interleukin 1 receptor, type I
IRS2 insulin receptor substrate 2
KLF4 Kruppel-like factor 4 (gut)
LMO3 LIM domain only 3 (rhombotin-like 2)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAL mal, T-cell differentiation protein
MSLN mesothelin
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NRGN neurogranin (protein kinase C substrate, RC3)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
RIN2 Ras and Rab interactor 2
RPL10 ribosomal protein L10
RSRP1 arginine/serine-rich protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCGB2A2 secretoglobin, family 2A, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFTPA2 surfactant protein A2
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC38A2 solute carrier family 38, member 2
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF7 serine/arginine-rich splicing factor 7
TLR4 toll-like receptor 4
TM9SF3 transmembrane 9 superfamily member 3
TNS3 tensin 3
TSPAN8 tetraspanin 8
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
ZNF395 zinc finger protein 395
ZNF512B zinc finger protein 512B
ZNF589 zinc finger protein 589