BRD-K64857848_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K64857848_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACSL3 acyl-CoA synthetase long-chain family member 3
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ARG1 arginase 1
ARHGAP32 Rho GTPase activating protein 32
ARID4B AT rich interactive domain 4B (RBP1-like)
BAMBI BMP and activin membrane-bound inhibitor
BIK BCL2-interacting killer (apoptosis-inducing)
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C4BPA complement component 4 binding protein, alpha
CADM1 cell adhesion molecule 1
CAMP cathelicidin antimicrobial peptide
CCDC85B coiled-coil domain containing 85B
CCNG2 cyclin G2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CLU clusterin
COL15A1 collagen, type XV, alpha 1
CTH cystathionine gamma-lyase
CTR9 CTR9, Paf1/RNA polymerase II complex component
CXADR coxsackie virus and adenovirus receptor
DEFA4 defensin, alpha 4, corticostatin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM46C family with sequence similarity 46, member C
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GAGE3 G antigen 3
GC group-specific component (vitamin D binding protein)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRN granulin
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
INSIG1 insulin induced gene 1
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
LGALS4 lectin, galactoside-binding, soluble, 4
LYZ lysozyme
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
MUC2 mucin 2, oligomeric mucus/gel-forming
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
ORM1 orosomucoid 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PER3 period circadian clock 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SPDEF SAM pointed domain containing ETS transcription factor
SPTAN1 spectrin, alpha, non-erythrocytic 1
STOM stomatin
TIMP3 TIMP metallopeptidase inhibitor 3
TMC5 transmembrane channel-like 5
TOB1 transducer of ERBB2, 1
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
WDR26 WD repeat domain 26
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOD apolipoprotein D
BEX1 brain expressed, X-linked 1
CBR3 carbonyl reductase 3
CCND1 cyclin D1
COASY CoA synthase
COCH cochlin
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL14 chemokine (C-X-C motif) ligand 14
DLC1 DLC1 Rho GTPase activating protein
EDN1 endothelin 1
FAM57A family with sequence similarity 57, member A
FBXL12 F-box and leucine-rich repeat protein 12
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GSTO1 glutathione S-transferase omega 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INTS3 integrator complex subunit 3
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
LRRC41 leucine rich repeat containing 41
LXN latexin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
OXTR oxytocin receptor
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDLIM2 PDZ and LIM domain 2 (mystique)
PFKP phosphofructokinase, platelet
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PNMA2 paraneoplastic Ma antigen 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCAN1 regulator of calcineurin 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS4 regulator of G-protein signaling 4
RHOBTB3 Rho-related BTB domain containing 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SORBS3 sorbin and SH3 domain containing 3
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STXBP2 syntaxin binding protein 2
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMSB15B thymosin beta 15B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
XIST X inactive specific transcript (non-protein coding)