BRD-K64800655_PHA-793887_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K64800655_PHA-793887_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
AHCYL1 adenosylhomocysteinase-like 1
ASCL1 achaete-scute family bHLH transcription factor 1
BTBD3 BTB (POZ) domain containing 3
CALB1 calbindin 1, 28kDa
CHGB chromogranin B
COL4A5 collagen, type IV, alpha 5
DCT dopachrome tautomerase
ETNK1 ethanolamine kinase 1
GAA glucosidase, alpha; acid
GAGE3 G antigen 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOPX HOP homeobox
IFI27 interferon, alpha-inducible protein 27
L1CAM L1 cell adhesion molecule
LAMP2 lysosomal-associated membrane protein 2
LGMN legumain
LMO3 LIM domain only 3 (rhombotin-like 2)
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NEBL nebulette
NLRP2 NLR family, pyrin domain containing 2
PCP4 Purkinje cell protein 4
PGC progastricsin (pepsinogen C)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRAME preferentially expressed antigen in melanoma
PRKCQ protein kinase C, theta
PRSS21 protease, serine, 21 (testisin)
PVALB parvalbumin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RHOB ras homolog family member B
SCARB2 scavenger receptor class B, member 2
SDC4 syndecan 4
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
CA2 carbonic anhydrase II
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN3 claudin 3
COL1A1 collagen, type I, alpha 1
CYBA cytochrome b-245, alpha polypeptide
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAS Fas cell surface death receptor
FBXO21 F-box protein 21
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTPBP8 GTP-binding protein 8 (putative)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H2AFV H2A histone family, member V
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIAA0355 KIAA0355
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM7 minichromosome maintenance complex component 7
NDC80 NDC80 kinetochore complex component
NDUFA4 NDUFA4, mitochondrial complex associated
NUSAP1 nucleolar and spindle associated protein 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX2 peroxiredoxin 2
PSAT1 phosphoserine aminotransferase 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RPA3 replication protein A3, 14kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
SCGB2A1 secretoglobin, family 2A, member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SMC4 structural maintenance of chromosomes 4
STMN1 stathmin 1
TBC1D4 TBC1 domain family, member 4
TLE4 transducin-like enhancer of split 4
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM29 tripartite motif containing 29
TSPYL5 TSPY-like 5
TTK TTK protein kinase