BRD-K64800655_PHA-793887_LNCAP_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K64800655_PHA-793887_LNCAP_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CFB complement factor B
CFD complement factor D (adipsin)
CKB creatine kinase, brain
COCH cochlin
CRYAB crystallin, alpha B
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DMBT1 deleted in malignant brain tumors 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
FAS Fas cell surface death receptor
FHL1 four and a half LIM domains 1
GSTT1 glutathione S-transferase theta 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HBB hemoglobin, beta
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MX2 MX dynamin-like GTPase 2
NES nestin
NLGN4X neuroligin 4, X-linked
NPY1R neuropeptide Y receptor Y1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
STK17A serine/threonine kinase 17a
SUB1 SUB1 homolog (S. cerevisiae)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNGR3 synaptogyrin 3
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TSPAN8 tetraspanin 8
TTC39A tetratricopeptide repeat domain 39A
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD163 CD163 molecule
CD69 CD69 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CKAP4 cytoskeleton-associated protein 4
COL15A1 collagen, type XV, alpha 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
ECM1 extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
GATA3 GATA binding protein 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
ITGA6 integrin, alpha 6
KLK10 kallikrein-related peptidase 10
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
LMO4 LIM domain only 4
LPAR6 lysophosphatidic acid receptor 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NQO1 NAD(P)H dehydrogenase, quinone 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PMM2 phosphomannomutase 2
PSRC1 proline/serine-rich coiled-coil 1
RAD23B RAD23 homolog B (S. cerevisiae)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
SCGB1D2 secretoglobin, family 1D, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TYRP1 tyrosinase-related protein 1
ZFP36L2 ZFP36 ring finger protein-like 2