BRD-K64800655_PHA-793887_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

260 genes differentially expressed following the BRD-K64800655_PHA-793887_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABHD6 abhydrolase domain containing 6
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
AKAP8L A kinase (PRKA) anchor protein 8-like
ANO10 anoctamin 10
ANXA4 annexin A4
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA12 carbonic anhydrase XII
CCDC85B coiled-coil domain containing 85B
CD24 CD24 molecule
CDCP1 CUB domain containing protein 1
CFB complement factor B
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
CYB5R1 cytochrome b5 reductase 1
DARS aspartyl-tRNA synthetase
DDR1 discoidin domain receptor tyrosine kinase 1
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DEGS1 delta(4)-desaturase, sphingolipid 1
DERL1 derlin 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPP4 dipeptidyl-peptidase 4
EMC3 ER membrane protein complex subunit 3
ENO2 enolase 2 (gamma, neuronal)
ERO1L ERO1-like (S. cerevisiae)
F12 coagulation factor XII (Hageman factor)
FAM162A family with sequence similarity 162, member A
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FGG fibrinogen gamma chain
FKBP14 FK506 binding protein 14, 22 kDa
FKBP1A FK506 binding protein 1A, 12kDa
GAA glucosidase, alpha; acid
GALNS galactosamine (N-acetyl)-6-sulfatase
GCLC glutamate-cysteine ligase, catalytic subunit
GOLT1B golgi transport 1B
GUK1 guanylate kinase 1
H2BFS H2B histone family, member S (pseudogene)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HK2 hexokinase 2
HP haptoglobin
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
ICAM3 intercellular adhesion molecule 3
IFI27 interferon, alpha-inducible protein 27
INSIG2 insulin induced gene 2
IPO13 importin 13
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MMD monocyte to macrophage differentiation-associated
MXI1 MAX interactor 1, dimerization protein
MZB1 marginal zone B and B1 cell-specific protein
NCF4 neutrophil cytosolic factor 4, 40kDa
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
ORM1 orosomucoid 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDZK1IP1 PDZK1 interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PGC progastricsin (pepsinogen C)
PGK1 phosphoglycerate kinase 1
PON2 paraoxonase 2
PRR7 proline rich 7 (synaptic)
RPL31 ribosomal protein L31
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TESC tescalcin
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TM9SF4 transmembrane 9 superfamily protein member 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TMEM5 transmembrane protein 5
TMEM59 transmembrane protein 59
TNNT1 troponin T type 1 (skeletal, slow)
TPST2 tyrosylprotein sulfotransferase 2
TRAPPC6A trafficking protein particle complex 6A
TRPS1 trichorhinophalangeal syndrome I
UBXN4 UBX domain protein 4
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA2 annexin A2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKB aurora kinase B
BCLAF1 BCL2-associated transcription factor 1
BLMH bleomycin hydrolase
C2CD5 C2 calcium-dependent domain containing 5
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CIRBP cold inducible RNA binding protein
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CXCL10 chemokine (C-X-C motif) ligand 10
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DAZAP2 DAZ associated protein 2
DDIT4 DNA-damage-inducible transcript 4
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FERMT2 fermitin family member 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXM1 forkhead box M1
FUS FUS RNA binding protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HAS2 hyaluronan synthase 2
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGN2 high mobility group nucleosomal binding domain 2
HMOX1 heme oxygenase 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IL7R interleukin 7 receptor
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIAA0355 KIAA0355
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LBR lamin B receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MCL1 myeloid cell leukemia 1
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MID1 midline 1
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAP1L1 nucleosome assembly protein 1-like 1
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRG1 neuregulin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
PLSCR4 phospholipid scramblase 4
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSRC1 proline/serine-rich coiled-coil 1
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFPQ splicing factor proline/glutamine-rich
SFRP4 secreted frizzled-related protein 4
SIRT1 sirtuin 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPC25 SPC25, NDC80 kinetochore complex component
SRSF3 serine/arginine-rich splicing factor 3
SRSF5 serine/arginine-rich splicing factor 5
STMN1 stathmin 1
SULF1 sulfatase 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYT1 synaptotagmin I
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN transgelin
TCF4 transcription factor 4
THBS1 thrombospondin 1
TLE4 transducin-like enhancer of split 4
TMEM47 transmembrane protein 47
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TRMT5 tRNA methyltransferase 5
TSPAN8 tetraspanin 8
TTK TTK protein kinase
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
U2SURP U2 snRNP-associated SURP domain containing
UBE2C ubiquitin-conjugating enzyme E2C
WNT5A wingless-type MMTV integration site family, member 5A
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)