BRD-K64800655_PHA-793887_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K64800655_PHA-793887_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARL4A ADP-ribosylation factor-like 4A
ATF3 activating transcription factor 3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
C8ORF4 chromosome 8 open reading frame 4
CD24 CD24 molecule
CHPT1 choline phosphotransferase 1
COL14A1 collagen, type XIV, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL2 chemokine (C-X-C motif) ligand 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO2 deiodinase, iodothyronine, type II
E2F5 E2F transcription factor 5, p130-binding
EDNRA endothelin receptor type A
EFS embryonal Fyn-associated substrate
FBLN1 fibulin 1
FOLR1 folate receptor 1 (adult)
GPM6A glycoprotein M6A
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
ICAM3 intercellular adhesion molecule 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0226L KIAA0226-like
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MATN2 matrilin 2
MICALL1 MICAL-like 1
MID1 midline 1
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MXI1 MAX interactor 1, dimerization protein
NARFL nuclear prelamin A recognition factor-like
NDP Norrie disease (pseudoglioma)
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PFKP phosphofructokinase, platelet
PID1 phosphotyrosine interaction domain containing 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PKP2 plakophilin 2
QPCT glutaminyl-peptide cyclotransferase
RAG1 recombination activating gene 1
RUNX3 runt-related transcription factor 3
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
TOP1 topoisomerase (DNA) I
TPD52 tumor protein D52
TRAF5 TNF receptor-associated factor 5
USP6NL USP6 N-terminal like
UST uronyl-2-sulfotransferase
WDR61 WD repeat domain 61
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BIRC5 baculoviral IAP repeat containing 5
C2CD5 C2 calcium-dependent domain containing 5
CAPN2 calpain 2, (m/II) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCR2 chemokine (C-C motif) receptor 2
CD163 CD163 molecule
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DLK1 delta-like 1 homolog (Drosophila)
DPYD dihydropyrimidine dehydrogenase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EVI2A ecotropic viral integration site 2A
FAM129A family with sequence similarity 129, member A
FAP fibroblast activation protein, alpha
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FST follistatin
FSTL1 follistatin-like 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB6 homeobox B6
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INSIG1 insulin induced gene 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LBR lamin B receptor
LDLR low density lipoprotein receptor
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LY6E lymphocyte antigen 6 complex, locus E
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
PARP2 poly (ADP-ribose) polymerase 2
PBX1 pre-B-cell leukemia homeobox 1
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
QDPR quinoid dihydropteridine reductase
RACGAP1 Rac GTPase activating protein 1
RNF130 ring finger protein 130
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON2 spondin 2, extracellular matrix protein
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRMT5 tRNA methyltransferase 5
TTK TTK protein kinase
VCAN versican