BRD-K64800655_PHA-793887_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K64800655_PHA-793887_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
CCND2 cyclin D2
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CERS6 ceramide synthase 6
CHRDL1 chordin-like 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS2 dehydrogenase/reductase (SDR family) member 2
EGFL6 EGF-like-domain, multiple 6
FOLR1 folate receptor 1 (adult)
GATA3 GATA binding protein 3
GOLGA8A golgin A8 family, member A
GPC3 glypican 3
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
ICAM1 intercellular adhesion molecule 1
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
LDOC1 leucine zipper, down-regulated in cancer 1
LRP10 low density lipoprotein receptor-related protein 10
METTL7A methyltransferase like 7A
MYO1B myosin IB
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDZD2 PDZ domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
RBP4 retinol binding protein 4, plasma
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
S100A9 S100 calcium binding protein A9
SATB1 SATB homeobox 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBR3 transforming growth factor, beta receptor III
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
VCL vinculin
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BANF1 barrier to autointegration factor 1
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC5 baculoviral IAP repeat containing 5
BMP4 bone morphogenetic protein 4
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALB1 calbindin 1, 28kDa
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CP ceruloplasmin (ferroxidase)
CRLF1 cytokine receptor-like factor 1
DEPTOR DEP domain containing MTOR-interacting protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELANE elastase, neutrophil expressed
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
EYA2 EYA transcriptional coactivator and phosphatase 2
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6A glycoprotein M6A
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
H2AFX H2A histone family, member X
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT15 keratin 15, type I
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MARCKSL1 MARCKS-like 1
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MSH2 mutS homolog 2
MSLN mesothelin
MYLK myosin light chain kinase
NEK2 NIMA-related kinase 2
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PLK1 polo-like kinase 1
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRTN3 proteinase 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTMA prothymosin, alpha
PUF60 poly-U binding splicing factor 60KDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS13 regulator of G-protein signaling 13
SALL1 spalt-like transcription factor 1
SCRG1 stimulator of chondrogenesis 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TRMT5 tRNA methyltransferase 5
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)