BRD-K64800655_PHA-793887_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K64800655_PHA-793887_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AREG amphiregulin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BHLHE41 basic helix-loop-helix family, member e41
BLCAP bladder cancer associated protein
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSZ cathepsin Z
CTTN cortactin
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
FAS Fas cell surface death receptor
FBXO2 F-box protein 2
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPH1 heat shock 105kDa/110kDa protein 1
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
LDOC1 leucine zipper, down-regulated in cancer 1
LRRN3 leucine rich repeat neuronal 3
MAOB monoamine oxidase B
MXRA7 matrix-remodelling associated 7
PDZK1IP1 PDZK1 interacting protein 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RAB29 RAB29, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RSAD2 radical S-adenosyl methionine domain containing 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SESN1 sestrin 1
SIRT3 sirtuin 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOX9 SRY (sex determining region Y)-box 9
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TTC39A tetratricopeptide repeat domain 39A
VEGFC vascular endothelial growth factor C
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CD302 CD302 molecule
CDC20 cell division cycle 20
CDH19 cadherin 19, type 2
CDK1 cyclin-dependent kinase 1
CDK14 cyclin-dependent kinase 14
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFH complement factor H
CHL1 cell adhesion molecule L1-like
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRB14 growth factor receptor-bound protein 14
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB7 homeobox B7
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LPL lipoprotein lipase
LTF lactotransferrin
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTTG1 pituitary tumor-transforming 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RPL36AL ribosomal protein L36a-like
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF3 transcription factor 3
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMEM47 transmembrane protein 47
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)