BRD-K64800655_HY-11001_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

277 genes differentially expressed following the BRD-K64800655_HY-11001_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANOS1 anosmin 1
APLNR apelin receptor
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
BLNK B-cell linker
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CD24 CD24 molecule
CD48 CD48 molecule
CD86 CD86 molecule
CDC42 cell division cycle 42
CDC5L cell division cycle 5-like
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP70 centrosomal protein 70kDa
CES2 carboxylesterase 2
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLCA4 chloride channel accessory 4
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
CPE carboxypeptidase E
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFA4 defensin, alpha 4, corticostatin
DLX2 distal-less homeobox 2
EDNRA endothelin receptor type A
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EXPH5 exophilin 5
F11R F11 receptor
FN1 fibronectin 1
FRZB frizzled-related protein
GAGE3 G antigen 3
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GLT8D2 glycosyltransferase 8 domain containing 2
GM2A GM2 ganglioside activator
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA13 heat shock protein 70kDa family, member 13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
KRT13 keratin 13, type I
KRT4 keratin 4, type II
LRRC17 leucine rich repeat containing 17
MAN2A1 mannosidase, alpha, class 2A, member 1
MEIS2 Meis homeobox 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NCAM1 neural cell adhesion molecule 1
NID1 nidogen 1
NLRP2 NLR family, pyrin domain containing 2
OLFM4 olfactomedin 4
PBX3 pre-B-cell leukemia homeobox 3
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PRKCI protein kinase C, iota
PRR15L proline rich 15-like
PRTN3 proteinase 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRO protein tyrosine phosphatase, receptor type, O
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SOCS2 suppressor of cytokine signaling 2
STC1 stanniocalcin 1
SULF1 sulfatase 1
TKTL1 transketolase-like 1
TPD52 tumor protein D52
TREM2 triggering receptor expressed on myeloid cells 2
TSPAN7 tetraspanin 7
UBQLN2 ubiquilin 2
VAMP8 vesicle-associated membrane protein 8
WT1 Wilms tumor 1
ZBED2 zinc finger, BED-type containing 2
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AACS acetoacetyl-CoA synthetase
AATF apoptosis antagonizing transcription factor
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG2 adhesion G protein-coupled receptor G2
ADIPOQ adiponectin, C1Q and collagen domain containing
AGTR1 angiotensin II receptor, type 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOD apolipoprotein D
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPH aspartate beta-hydroxylase
ATF5 activating transcription factor 5
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BLVRA biliverdin reductase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTBD3 BTB (POZ) domain containing 3
BUB3 BUB3 mitotic checkpoint protein
C10ORF10 chromosome 10 open reading frame 10
CALML5 calmodulin-like 5
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNB2 cyclin B2
CCND1 cyclin D1
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHRDL1 chordin-like 1
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CRIP1 cysteine-rich protein 1 (intestinal)
CTPS1 CTP synthase 1
CTTN cortactin
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM57A family with sequence similarity 57, member A
FAR2 fatty acyl CoA reductase 2
FASN fatty acid synthase
FLG filaggrin
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GHR growth hormone receptor
GLOD4 glyoxalase domain containing 4
GLRX glutaredoxin (thioltransferase)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
H3F3B H3 histone, family 3B (H3.3B)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP6 insulin-like growth factor binding protein 6
IL1R2 interleukin 1 receptor, type II
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGA7 integrin, alpha 7
JAK1 Janus kinase 1
KDM5D lysine (K)-specific demethylase 5D
KIAA1033 KIAA1033
KRT14 keratin 14, type I
LAT2 linker for activation of T cells family, member 2
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAP3K4 mitogen-activated protein kinase kinase kinase 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MID1 midline 1
MID1IP1 MID1 interacting protein 1
MRPL12 mitochondrial ribosomal protein L12
MVP major vault protein
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PANK2 pantothenate kinase 2
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDHX pyruvate dehydrogenase complex, component X
PFKP phosphofructokinase, platelet
PHYH phytanoyl-CoA 2-hydroxylase
PIP prolactin-induced protein
PITPNB phosphatidylinositol transfer protein, beta
PLA2G16 phospholipase A2, group XVI
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PRKCDBP protein kinase C, delta binding protein
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTX3 pentraxin 3, long
PWP1 PWP1 homolog (S. cerevisiae)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RPL36AL ribosomal protein L36a-like
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RRBP1 ribosome binding protein 1
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase
S100B S100 calcium binding protein B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT9 septin 9
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORBS3 sorbin and SH3 domain containing 3
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNM synemin, intermediate filament protein
TBC1D16 TBC1 domain family, member 16
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TIMP4 TIMP metallopeptidase inhibitor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPM2 tropomyosin 2 (beta)
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN14 tetraspanin 14
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
XPO1 exportin 1
YBX3 Y box binding protein 3
ZMYM2 zinc finger, MYM-type 2