BRD-K64642496_-666_SW620_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

136 genes differentially expressed following the BRD-K64642496_-666_SW620_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADM adrenomedullin
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BEX4 brain expressed, X-linked 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLIC4 chloride intracellular channel 4
COL6A3 collagen, type VI, alpha 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DLD dihydrolipoamide dehydrogenase
DSP desmoplakin
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXB2 homeobox B2
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
NFIL3 nuclear factor, interleukin 3 regulated
NT5E 5'-nucleotidase, ecto (CD73)
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PYGB phosphorylase, glycogen; brain
RAB25 RAB25, member RAS oncogene family
RIPK2 receptor-interacting serine-threonine kinase 2
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAI2 snail family zinc finger 2
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
THBS2 thrombospondin 2
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFAND1 zinc finger, AN1-type domain 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK6 cyclin-dependent kinase 6
CHMP2A charged multivesicular body protein 2A
CLU clusterin
COPS7A COP9 signalosome subunit 7A
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCXR dicarbonyl/L-xylulose reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
GLIPR1 GLI pathogenesis-related 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
IRX5 iroquois homeobox 5
LYRM1 LYR motif containing 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1 PDZ domain containing 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RHOBTB3 Rho-related BTB domain containing 3
RPA3 replication protein A3, 14kDa
SAC3D1 SAC3 domain containing 1
SCAND1 SCAN domain containing 1
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TAGLN transgelin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGOLN2 trans-golgi network protein 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TRIB2 tribbles pseudokinase 2
UBE2S ubiquitin-conjugating enzyme E2S