BRD-K64642496_-666_MCF7_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K64642496_-666_MCF7_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AGTPBP1 ATP/GTP binding protein 1
ANXA4 annexin A4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP11B ATPase, class VI, type 11B
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
FAM129A family with sequence similarity 129, member A
GAGE3 G antigen 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HMGN4 high mobility group nucleosomal binding domain 4
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
LDLR low density lipoprotein receptor
METTL7A methyltransferase like 7A
MPZL2 myelin protein zero-like 2
MTA1 metastasis associated 1
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NFIL3 nuclear factor, interleukin 3 regulated
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PPAP2C phosphatidic acid phosphatase type 2C
PRAME preferentially expressed antigen in melanoma
PRNP prion protein
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
STC2 stanniocalcin 2
TGFA transforming growth factor, alpha
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase
ZFAND1 zinc finger, AN1-type domain 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AK1 adenylate kinase 1
AKIRIN1 akirin 1
ATF5 activating transcription factor 5
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF5A eukaryotic translation initiation factor 5A
FOLR1 folate receptor 1 (adult)
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GPM6B glycoprotein M6B
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IL13RA2 interleukin 13 receptor, alpha 2
JMJD6 jumonji domain containing 6
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDGFA platelet-derived growth factor alpha polypeptide
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIF peptidylprolyl isomerase F
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTPRC protein tyrosine phosphatase, receptor type, C
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SRSF2 serine/arginine-rich splicing factor 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
USP46 ubiquitin specific peptidase 46