BRD-K64642496_-666_MCF7_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

415 genes differentially expressed following the BRD-K64642496_-666_MCF7_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND2 cyclin D2
CD163 CD163 molecule
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CDC34 cell division cycle 34
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP4A charged multivesicular body protein 4A
CLIC4 chloride intracellular channel 4
COL15A1 collagen, type XV, alpha 1
CTSL cathepsin L
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DSC2 desmocollin 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EHF ets homologous factor
EIF4B eukaryotic translation initiation factor 4B
ELN elastin
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FTH1 ferritin, heavy polypeptide 1
FXYD5 FXYD domain containing ion transport regulator 5
FYN FYN proto-oncogene, Src family tyrosine kinase
GAA glucosidase, alpha; acid
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATAD1 GATA zinc finger domain containing 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP4 insulin-like growth factor binding protein 4
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KDM7A lysine (K)-specific demethylase 7A
KIAA0368 KIAA0368
KIF2A kinesin heavy chain member 2A
KIZ kizuna centrosomal protein
KLF4 Kruppel-like factor 4 (gut)
KLK6 kallikrein-related peptidase 6
KRT23 keratin 23, type I
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRC8D leucine rich repeat containing 8 family, member D
MAL mal, T-cell differentiation protein
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MINA MYC induced nuclear antigen
MMP7 matrix metallopeptidase 7
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2C1 nuclear receptor subfamily 2, group C, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PELI1 pellino E3 ubiquitin protein ligase 1
PFDN2 prefoldin subunit 2
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAF2 PRA1 domain family, member 2
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAD50 RAD50 homolog (S. cerevisiae)
RANBP2 RAN binding protein 2
RAP1GAP RAP1 GTPase activating protein
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSL1D1 ribosomal L1 domain containing 1
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK3 SIK family kinase 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
SRGN serglycin
STC2 stanniocalcin 2
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TARS threonyl-tRNA synthetase
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCEA1 transcription elongation factor A (SII), 1
TES testin LIM domain protein
TGFA transforming growth factor, alpha
TGIF1 TGFB-induced factor homeobox 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TP53 tumor protein p53
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN12 tetraspanin 12
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3
ZBED2 zinc finger, BED-type containing 2
ZFAND1 zinc finger, AN1-type domain 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMAT3 zinc finger, matrin-type 3
ZNF146 zinc finger protein 146
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABHD2 abhydrolase domain containing 2
ACOT7 acyl-CoA thioesterase 7
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGR2 anterior gradient 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPT1 angiopoietin 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
AURKB aurora kinase B
B3GNT1
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
C7 complement component 7
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CCNE2 cyclin E2
CCNF cyclin F
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPM centromere protein M
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHEK1 checkpoint kinase 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CRYZ crystallin, zeta (quinone reductase)
CXCL14 chemokine (C-X-C motif) ligand 14
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEK DEK proto-oncogene
DHFR dihydrofolate reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNA2 DNA replication helicase/nuclease 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTYMK deoxythymidylate kinase (thymidylate kinase)
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
EFHD1 EF-hand domain family, member D1
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP2 epithelial membrane protein 2
ENDOD1 endonuclease domain containing 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
FAM111A family with sequence similarity 111, member A
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FBXO9 F-box protein 9
FEN1 flap structure-specific endonuclease 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN3KRP fructosamine 3 kinase related protein
FOXM1 forkhead box M1
FSD1 fibronectin type III and SPRY domain containing 1
GAS2L1 growth arrest-specific 2 like 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLO1 glyoxalase I
GMNN geminin, DNA replication inhibitor
GPER1 G protein-coupled estrogen receptor 1
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSBP1 heat shock factor binding protein 1
HSPB11 heat shock protein family B (small), member 11
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
KANK2 KN motif and ankyrin repeat domains 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
LAGE3 L antigen family, member 3
LIG1 ligase I, DNA, ATP-dependent
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MICB MHC class I polypeptide-related sequence B
MKI67 marker of proliferation Ki-67
MPC2 mitochondrial pyruvate carrier 2
MSMB microseminoprotein, beta-
MXRA7 matrix-remodelling associated 7
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PHB prohibitin
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PSMC3IP PSMC3 interacting protein
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSRC1 proline/serine-rich coiled-coil 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB1B RAB1B, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RANBP1 RAN binding protein 1
RBBP7 retinoblastoma binding protein 7
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS4 regulator of G-protein signaling 4
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RUSC1 RUN and SH3 domain containing 1
SELT selenoprotein T
SERHL2 serine hydrolase-like 2
SFTPA2 surfactant protein A2
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP1 S-phase kinase-associated protein 1
SLBP stem-loop binding protein
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SMC2 structural maintenance of chromosomes 2
SMS spermine synthase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
STRA13 stimulated by retinoic acid 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFDP1 transcription factor Dp-1
TK1 thymidine kinase 1, soluble
TMEM106C transmembrane protein 106C
TMEM14A transmembrane protein 14A
TMEM164 transmembrane protein 164
TMPO thymopoietin
TMSB15A thymosin beta 15a
TMSB15B thymosin beta 15B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2N ubiquitin-conjugating enzyme E2N
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
WDR61 WD repeat domain 61
ZWINT ZW10 interacting kinetochore protein